Figure 4From: Metformin therapy in a hyperandrogenic anovulatory mutant murine model with polycystic ovarian syndrome characteristics improves oocyte maturity during superovulation Ovarian follicular counts (non atretic) following in vivo metformin exposure. Horizontal axis indicates follicle stage. Follicle counts were performed in mice (N = 3) who underwent 7 weeks of oral metformin treatment or no treatment (control) (A, B, C). C = control, MF = metformin. All counts of this figure included 3 replicates with N = 1 mouse. Error bars represent SEM. Follicular counts (of any stage) did not change (relative to control group) following metformin treatment. Overall, db/db mice demonstrated a significantly greater total follicular endowment (sum of all non atretic follicle stages) than WT and ob/ob mice (D). Different designated letters among genotypes in D indicates statistical difference with p = 0.01 (ANOVA).Back to article page