Figure 2

Schematic diagram of signaling pathways that are involved in normal and cancer stem cell biology. Wnt, Shh and Notch1 pathways have been shown to contribute to the self-renewal of stem cells and/or progenitors in a variety of organs, including the ovarian system. When deregulated, these pathways can contribute to oncogenesis. Mutations of these pathways have been associated with a number of carcinomas.