Table 2 Summary of promoter and targeted genes of granulosa cell tumors (GCT).
From: Ovarian cancer mouse models: a summary of current models and their limitations
Authors | Promoter | Targeted gene | Tumorigenesis | Limitation |
|---|---|---|---|---|
Kananen et al. (1995) | α-subunit of inhibin | SV40 TAg | Yes |  |
Nilson et al. (2000) | α-subunit of inhibin | LHβCTP | Yes | Females unable to reproduce |
Garson et al. (2003) | OSP-1 | SV40 TAg | Yes | developed tumors |
Boerboom et al. (2005) | MISIIR/Cre | mutant β-catenin | Yes | Transient expression |
Lague et al. (2008) | MISIIR/Cre | PTEN-/- & CTNNB1-/- | Yes | Transient expression |