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Table 1 Relationship between prechemotherapy absolute serum CA125 levels and survival in ovarian cancer

From: Role of CA125 in predicting ovarian cancer survival - a review of the epidemiological literature

First Author, Year, Study Place Data Collection Study Design Sample Size Groups being Compared RR/HR, (95% CI), P-Value Conclusion Variables Adjusted for
Markman M, 2006, USA, [37] NA Longitudinal study 101 ≤ 35 U/ml, > 35-- < 100 U/ml, ≥ 100 U/ml NA Reduction in serum CA-125 concentration over the initial 2 cycles of chemotherapy was an independent predictor of survival NA
Riedinger JM, 2006, France [38] 1988 to 1996 Multicentric retrospective study 631 ≤ 230 kU/L & > 230 kU/L Univariate analysis 0.77 (0.73--0.81), < 0.0001 Pre-chemotherapy CA125 had a univariate prognostic value for disease free survival and overall survival NA
Gronlund B, 2005, Denmark [39] Dec 1993 to Sep 1998 Prospective study 70 Multiple cutoffs of 35, 65, 132 & 339 U/mL NA The pretreatment CA125 level was not found to be significantly associated with survival by any of the cutoffs FIGO stage, histology, localization of tumor relapse, size of tumor relapse, CASA level
Gadducci A, 1995, Italy [40] 1986 to 1992 Multicentric retrospective study 225 < 500 U/ml, ≥ 500 U/ml NA Survival was found to be significantly related to serum CA 125 before the third cycle FIGO stage, tumor grade, residual disease, CA125 half life
Ron IG, 1994, Israel [41] Feb 1987 to Dec 1990 Prospective study 48 35-100 U/ml, 101-299 U/ml, 300-499 U/ml, 500 U/ml NA, < 0.0001 Early response (CA125 normalcy by the end of the second chemotherapeutic course) was a highly significant predictor of disease-free survival at 12 months Age, FIGO stage, histology, grade, residual tumor, ascites
Davidson NG, 1991, [42] Sep 1985 to Sep 1987 Convenience sample 55 < 50 kU/l, 125 ≥ 50 kU/l NA, < 0.003 Prechemotherapy CA125 level taken 4 weeks after debulking surgery may predict survival in ovarian cancer patients who undergo chemotherapy treatment Age, Histology, FIGO stage, tumor grade, residual disease
Rustin GJ, 1989, U.K. [43] April 1985 to Feb 1987 Prospective study 54 ≥ 35 U/ml, < 35 U/ml NA, 0.001 There was a highly significant relationship between the progression free survival time and the change in CA125 levels just prior to chemotherapy NA
van der Burg ME, 1988, Netherland [44] Sept 1979 to Dec 1983 Consecutive case series 85 ≤ 35 U/ml, 35-60 U/ml, > 60 U/ml NA The prechemotherapy level of CA125 on itself is strongly correlated with progression rate and the probability of progression within 3 years FIGO stage, histology, histological grade, postoperative tumor size