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Table 7 Relationship between nadir CA125 levels and survival in ovarian cancer

From: Role of CA125 in predicting ovarian cancer survival - a review of the epidemiological literature

First Author, Year, Study Place

Data Collection

Study Design

Sample Size

Groups being Compared

RR/HR, (95% CI), P-Value

Conclusion

Variables Adjusted for

Riedinger JM, 2008, France [64]

1996 to 2000

Multicentric Retrospective study

130

≤ 20 kU/L, > 20 kU/L

4.18 (2.65-6.62), < 0.0001

Nadir concentration, residual tumor volume and number of chemotherapy courses were found to be independent prognostic factors for disease free survival and overall survival

Chemotherapy courses, residual tumor

Riedinger JM, 2006, France [38]

1988 to 1996

Multicentric retrospective study

631

≤ 20 kU/L, > 20 kU/L

1.65 (1.28-2.12), < 0.0001

CA125 half life and nadir concentration are powerful independent prognostic factors. CA125 nadir concentration and time to nadir all had a univariate prognostic value for disease free survival and overall survival

Age, FIGO stage, residual tumor, CA125 half life

Crawford SM, 2005, [8]

1988 to 2000

Retrospective study

79

≤ 10 U/ml, 11--20 U/ml, 21--30 U/ml

NA, < 0.001

The nadir group was the only predictor of overall survival that remained very highly significant (P < 0.001) after the effect of the other factors was allowed for

Type of chemotherapy, CA125 level at course three

Gard GB, 1994, Australia [70]

1985 to 1991

Retrospective study

223

> 35 U/ml, 15-35 U/ml, < 15 U/ml

Uni- 3.23 (2.62-3.99), < 0.0001

Multi-0.85 (0.54-1.33), 0.476

The initial CA125 level and nadir CA125 level, although significant when considered alone, were not significant independent variables

Tumor types, FIGO stage, residual disease, CA125