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Table 7 Relationship between nadir CA125 levels and survival in ovarian cancer

From: Role of CA125 in predicting ovarian cancer survival - a review of the epidemiological literature

First Author, Year, Study Place Data Collection Study Design Sample Size Groups being Compared RR/HR, (95% CI), P-Value Conclusion Variables Adjusted for
Riedinger JM, 2008, France [64] 1996 to 2000 Multicentric Retrospective study 130 ≤ 20 kU/L, > 20 kU/L 4.18 (2.65-6.62), < 0.0001 Nadir concentration, residual tumor volume and number of chemotherapy courses were found to be independent prognostic factors for disease free survival and overall survival Chemotherapy courses, residual tumor
Riedinger JM, 2006, France [38] 1988 to 1996 Multicentric retrospective study 631 ≤ 20 kU/L, > 20 kU/L 1.65 (1.28-2.12), < 0.0001 CA125 half life and nadir concentration are powerful independent prognostic factors. CA125 nadir concentration and time to nadir all had a univariate prognostic value for disease free survival and overall survival Age, FIGO stage, residual tumor, CA125 half life
Crawford SM, 2005, [8] 1988 to 2000 Retrospective study 79 ≤ 10 U/ml, 11--20 U/ml, 21--30 U/ml NA, < 0.001 The nadir group was the only predictor of overall survival that remained very highly significant (P < 0.001) after the effect of the other factors was allowed for Type of chemotherapy, CA125 level at course three
Gard GB, 1994, Australia [70] 1985 to 1991 Retrospective study 223 > 35 U/ml, 15-35 U/ml, < 15 U/ml Uni- 3.23 (2.62-3.99), < 0.0001
Multi-0.85 (0.54-1.33), 0.476
The initial CA125 level and nadir CA125 level, although significant when considered alone, were not significant independent variables Tumor types, FIGO stage, residual disease, CA125