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Table 8 Relationship between time to reach nadir CA125 levels and survival in ovarian cancer

From: Role of CA125 in predicting ovarian cancer survival - a review of the epidemiological literature

First Author, Year, Study Place Data Collection Study Design Sample Size Groups being Compared RR/HR, (95% CI), P-Value Conclusion Variables Adjusted for
Riedinger J M, 2006, France [38] 1988 to 1996 Multicentric retrospective study 553 ≤ 72 days, > 72 days Univariate analysis 0.67 (0.63--0.71) < 0.0001 CA125 nadir concentration and time to nadir all had a univariate prognostic value for disease free survival and overall survival. In Cox models, nadir concentration was the most powerful prognostic factors for disease free survival NA
Frasci G, 1996, Italy [71] 1985 to 1990 Consecutive case series 54 ≤ 1 month, > 1 months 0.009 Survival of patients with advanced ovarian cancer could be accurately predicted by considering some pretreatment variables and time to CA125 normalization together, without performing second look laparotomy Residual tumor burden after surgery, Eastern Cooperative
Oncology Group (ECOG) performance status