Table 8 Relationship between time to reach nadir CA125 levels and survival in ovarian cancer
From: Role of CA125 in predicting ovarian cancer survival - a review of the epidemiological literature
First Author, Year, Study Place | Data Collection | Study Design | Sample Size | Groups being Compared | RR/HR, (95% CI), P-Value | Conclusion | Variables Adjusted for |
|---|---|---|---|---|---|---|---|
Riedinger J M, 2006, France [38] | 1988 to 1996 | Multicentric retrospective study | 553 | ≤ 72 days, > 72 days | Univariate analysis 0.67 (0.63--0.71) < 0.0001 | CA125 nadir concentration and time to nadir all had a univariate prognostic value for disease free survival and overall survival. In Cox models, nadir concentration was the most powerful prognostic factors for disease free survival | NA |
Frasci G, 1996, Italy [71] | 1985 to 1990 | Consecutive case series | 54 | ≤ 1 month, > 1 months | 0.009 | Survival of patients with advanced ovarian cancer could be accurately predicted by considering some pretreatment variables and time to CA125 normalization together, without performing second look laparotomy | Residual tumor burden after surgery, Eastern Cooperative Oncology Group (ECOG) performance status |