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Table 3 Comparative expression profile of mucins in different stages and histological types of ovarian cancer

From: Mucins in ovarian cancer diagnosis and therapy

Gene Normal Ovary Borderline
(Mucinous)
Low Stage (Stage 1-2) High Stage (Stage 3-4) Detection method
MUC1 +/- ++ + to +++ (in all histological types i.e. C, M, E, S) + to +++ (in all histological types i.e. C, M, E, S) ISH, NB, IHC [4750]
MUC2 ND +++ +++ (all histological types, primarily in mucinous type) + to ++ ISH, NB, IHC [4751]
MUC3 ND +++ (primarily in intestinal phenotype +++ (E, M) - to + ISH, NB [47, 48]
MUC4 - +++ (primarily in endocervical phenotype) +++ (all types i.e. C, M, E, S) - to ++ ISH, NB, IHC [47, 48]
MUC5AC ND ++ (primarily in gastric surface cell or mucinous type) ++ (E, M, S) ++ ISH, NB, [47, 48]
MUC5B ND ++ (Express primarily in endocervical phenotype) ++ (C, S) - to + ISH, NB [47, 48]
MUC13 ND + +++ (S, M) ++ (S, M) OMA, TMA, IHC [53, 97]
CA125/MUC16 - - (express in non-mucinous borderline tumors - to +++ (rarely express in mucinous tumors) + to +++ (rarely express in mucinous tumors) IHC [7679]
MUC17 - + - - [44, 97]
  1. Note: C, M, E, and S are abbreviated for clear cell, mucinous, endometroid and serous histological types of ovarian tumors, respectively.
  2. ISH, in-situ hybridization; NB, northern blotting; IHC, immunohistochemistry, TMA, tissue microarray, OMA, oligonucleotide microarray