Gene | Normal Ovary | Borderline (Mucinous) | Low Stage (Stage 1-2) | High Stage (Stage 3-4) | Detection method |
---|---|---|---|---|---|
MUC1 | +/- | ++ | + to +++ (in all histological types i.e. C, M, E, S) | + to +++ (in all histological types i.e. C, M, E, S) | |
MUC2 | ND | +++ | +++ (all histological types, primarily in mucinous type) | + to ++ | |
MUC3 | ND | +++ (primarily in intestinal phenotype | +++ (E, M) | - to + | |
MUC4 | - | +++ (primarily in endocervical phenotype) | +++ (all types i.e. C, M, E, S) | - to ++ | |
MUC5AC | ND | ++ (primarily in gastric surface cell or mucinous type) | ++ (E, M, S) | ++ | |
MUC5B | ND | ++ (Express primarily in endocervical phenotype) | ++ (C, S) | - to + | |
MUC13 | ND | + | +++ (S, M) | ++ (S, M) | |
CA125/MUC16 | - | - (express in non-mucinous borderline tumors | - to +++ (rarely express in mucinous tumors) | + to +++ (rarely express in mucinous tumors) | |
MUC17 | - | + | - | - |