Table 1 Effect ovarian cancer ascites on drug-induced cell death
Ovarian cancer ascites | Cisplatin IC50 (ng/ml) | Paclitaxel IC50 (ng/ml) | Doxorubicin IC50 (ng/ml) | Etoposide IC50 (ng/ml) | Vinorelbine IC50 (ng/ml) | TRAIL IC50 (ng/ml) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
fluids | - | + | - | + | - | + | - | + | - | + | - | + |
346 | 746 ± 38 | 1400 ± 24 | 16 ± 7 | 100 ± 9 | 86 ± 8 | 250 ± 15 | 2183 ± 147 | 7500 ± 245 | 4.1 ± 0.25 | 10 ± 1 | 8.4 ± 2.7 | 28.6 ± 4 |
432 | 746 ± 38 | 900 ± 43 | 16 ± 7 | 16 ± 3 | 86 ± 8 | 70 ± 10 | 2183 ± 147 | 2000 ± 87 | 4.1 ± 0.25 | 4.4 ± 0.4 | 8.4 ± 2.7 | 8.1 ± 2.8 |
488 | 746 ± 38 | 900 ± 23 | 16 ± 7 | 37 ± 5 | 86 ± 8 | 107 ± 13 | 2183 ± 147 | 6000 ± 184 | 4.1 ± 0.25 | 6.3 ± 1 | 8.4 ± 2.7 | 9.0 ± 3 |
508 | 746 ± 38 | 2300 ± 16 | 16 ± 7 | 16 ± 4 | 86 ± 8 | 145 ± 5 | 2183 ± 147 | >50000 | 4.1 ± 0.25 | >1000 | 8.4 ± 2.7 | 38 ± 4.2 |
509 | 746 ± 38 | 3000 ± 54 | 16 ± 7 | 80 ± 3 | 86 ± 8 | 750 ± 8 | 2183 ± 147 | >50000 | 4.1 ± 0.25 | >1000 | 8.4 ± 2.7 | 32 ± 3.1 |
551 | 746 ± 38 | 820 ± 47 | 16 ± 7 | 13 ± 4 | 86 ± 8 | 112 ± 12 | 2183 ± 147 | 4600 ± 231 | 4.1 ± 0.25 | 6.6 ± 0.2 | 8.4 ± 2.7 | 15 ± 5.4 |