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Table 3 Biodistribution of 99mTc-noscapine in Wister rats following i.v. injection.

From: Radiolabeling, biodistribution and gamma scintigraphy of noscapine hydrochloride in normal and polycystic ovary induced rats

ORGAN

PERCENT INJECTED DOSE/WHOLE ORGAN (± SEM)

 

TIME

 

15 min

1 h

2 h

4 h

24 h

Blood

0.22 ± .04

0.116 ± .05

0.156 ± .05

0.115 ± .03

0.0085 ± .002

Heart

0.048 ± .007

0.023 ± .01

0.019 ± 2.35

0.015 ± .007

0.002 ± .001

Liver

2.48 ± .78

2.05 ± .52

1.36 ± 1.15

1.01 ± 1.37

0.135 ± .17

Lungs

0.28 ± .03

0.123 ± .11

0.21 ± .21

0.093 ± .06

0.002 ± .001

Ovary

0.123 ± .1

0.093 ± .03

0.15 ± .036

0.531 ± 1.25

0.01 ± 0

Stomach

0.088 ± .08

0.048 ± .07

0.043 ± .01

0.025 ± .007

0.002 ± .001

Intestine

0.11 ± .06

0.079 ± .07

0.063 ± .02

0.03 ± .01

0.003 ± 0

Spleen

0.07 ± .005

0.725 ± .85

1.156 ± .75

0.59 ± .79

0.137 ± .18

Uterus

0.076 ± .05

0.04 ± .01

0.03 ± .01

0.02 ± 0

0.004 ± 0

Kidney

0.21 ± .127

0.39 ± .23

0.44 ± .136

0.56 ± .16

0.088 ± .054

Brain

0.01 ± .006

0.005 ± .0025

0.006 ± .001

0.008 ± .001

0.001 ± 0

  1. Data from five rats/group expressed as % injected dose/whole organ + SEM