Design of MSC-AR targeted to tumor marker. A) Schematic presentation of Artificial Receptor C6.5 (AR) used to obtain MSC-AR and genomes of adenoviral vectors for AR expression. B) Genetically modified adenoviral vectors provided efficient expression of AR on MSC membrane. MSC were transduced with Ad.AR or AdRGDpK7.AR at MOI 500 vp/cell. AR expression on MSC membrane was confirmed by staining cells with a-HA tag antibody. MSCs expressing AR are stained red.