Effect of the LXR agonist T0901317 on cellular morphology. CaOV3 cells were cultured and treated with DMSO (1%, A) or T0901317 at a concentration of 5 μM (B), 10 μM (C), 20 μM (D), 40 μM (E) or 50 μM (F) for a total of 48 hours. Cells were visualized microscopically (10X) and pictures taken. The pictures clearly demonstrate a significant effect on cellular morphology. At increasing doses of the LXR agonist, the cells appeared to have a decreased amount of cytoplasm with a concomitant decrease in cell cumber. At the doses of 40 μM and 50 μM, the cells appeared apoptotic with necrotic debris present in the media.