Figure 6From: CCR9 interactions support ovarian cancer cell survival and resistance to cisplatin-induced apoptosis in a PI3K-dependent and FAK-independent fashionInhibition of apoptotic signal in cisplatin resistant tumor cells. More than one mechanism is usually observed in resistant cells, and this contributes to the multi-factorial nature of cisplatin resistance. CCR9-dependent anti-apoptotic signalling in OvCa cells involves the PI3K/Akt cascade and phosphorylation of its downstream mediators, GSK-3β and FKHR.Back to article page