Figure 1

ELISA detection of serum LRG1. A) Serum LRG1 concentrations were determined for 58 ovarian cancer patients and 56 of the control patients. Box plots are presented here; the solid line indicates the median serum LRG1 for each group. Serum levels of LRG1 were significantly higher in the ovarian cancer sera than in control sera, after adjusting for age (p=0.0008). B) LRG1 in serum of individual patients with benign and malignant gynecological diseases. Median LRG1 values for each group are indicated by the solid bars. Dashed line indicates the mean LRG1 concentration from control serum in panel A. LRG1 concentrations are significantly higher in serum of women with ovarian cancer (serous and clear cell subtypes) than in serum of women with other gynecological diseases (p <0.0001). C) Receiver operator curves (ROC) for CA125 alone (blue line), LRG1 alone (red line) and LRG1 in combination with CA125 (green line). The area under the curve (AUC) for CA125 alone was 0.88, for LRG1 alone the AUC = 0.77, and the AUC for CA125 and LRG1 together was 0.89. There was no significant difference in sensitivity between CA125 alone and CA125 in combination with LRG1 (p=0.2728).