Longitudinal monitoring of CA125 levels provides additional information about survival in ovarian cancer

Table 4 Multivariate Cox Proportional Hazard Model

Independent Variable	Unit of increase	RR¹	95% CI	P-value
Age at presentation	1 year	1.003	0.98, 1.03	0.78
Prior treatment history	Newly diagnosed as referent	1.1	0.52, 2.2	0.86
Stage at Diagnosis
• Stage II		0.29	0.06, 1.5	0.15
• Stage III	Stage I as referent	1.4	0.61, 3.2	0.43
• Stage IV		1.7	0.57, 5.0	0.35
Change in CA125
• Normal to Normal		0.07	0.02, 0.26	<0.001
• High to Normal	High to High as referent	0.29	0.13, 0.65	0.003
• Normal to High		0.40	0.09, 1.7	0.21

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