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Figure 3 | Journal of Ovarian Research

Figure 3

From: Development of a syngeneic mouse model of epithelial ovarian cancer

Figure 3

Early tumor formation in Tg MISIIR-TAg-DR26 mice. The presence and extent of tumor formation in a 28-day old female TgMISIIR-TAg-DR26 mouse was confirmed by histopathological evaluation. A) Low power magnification (40x) of an H&E stained section of the reproductive tract showing the ovary and segments of the fallopian tube and uterus reveals an early-stage ovarian tumor indicated by the arrow. B) Immunostaining of an adjacent section shows TAg positive tumor cells in the ovary (arrowheads). TAg positive staining cells were also apparent in the epithelium of the fallopian tube and endometrium. The segment contained within the box is shown in (C) at higher magnification (100X). D) High power magnification (400X) of the boxed area in (C) showing the TAg positive epithelial cells of the endometrial glands. Calibration bar: A and B, 1 mm; C, 250 μm; D, 125 μm.

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