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Figure 1 | Journal of Ovarian Research

Figure 1

From: Effects of GnRH agonist treatment on steroidogenesis and folliculogenesis in the ovary of cyclic mice

Figure 1

Transverse sections of the ovaries (stained with haematoxylin-eosin) of cyclic mice showing histological changes following administration of different doses of GnRH-Ag: (A) The ovary of control mice showing normal corpus luteum (CL), healthy antral follicles (An) and a few atretic follicle (At); (B) ovary of the mice treated with 1 μg/day GnRH-Ag showing many healthy antral follicles (An), a few atretic follicles (At) and a few corpus luteum (CL); (C), (D) & (E) ovary of mice treated with 5 μg/day GnRH-Ag; (C) note the presence of many normal corpus luteum (CL), a few haemorrhagic corpus luteum and antral follicle (An); (D) normal antral follicle (An); (E) normal corpus luteum (CL); (F), (G) & (H) ovary of the mice treated with 25 μg/day of GnRH-Ag; (F) ovary showing many antral follicles (An) but a few corpus luteum (CL); (G) & (H) section of the ovary showing abnormal antral follicle. Granulosa cells (GCs) showing enlarged and vacuolated nuclei (black arrow), a few pyknotic nuclei (py) and thin and regressed theca cells (TC) layers. The oocytes (Oo) appeared highly vacuolated.

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