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Figure 8 | Journal of Ovarian Research

Figure 8

From: Differential expression of aldehyde dehydrogenase 1a1 (ALDH1) in normal ovary and serous ovarian tumors

Figure 8

Flow cytometry analysis of normal ovarian cells, benign and malignant tumor cells with ALDEFLUOR. The ALDH1 enzyme activity was calculated as a difference (Δ) in mean fluorescence intensity (MFI). The background in the presence of the ALDH1 inhibitor DEAB (shaded gray) was subtracted from the mean fluorescence intensity of cells incubated with ALDEFLUOR alone (black line) for each cell preparation. Normal ovarian cells (A-C; Δ = 92.3 ± 24 MFI) and benign tumor cells (D-F; Δ = 74 ± 18.7 MFI) show higher ALDH1 enzyme activity than malignant tumor cells (G-I; Δ = 15 ± 8.8 MFI) as depicted in the overlay histogram plots.

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