Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter

Table 1 Gene Regulation

Gene Symbol	Name	Entrez Gene ID	Group
Bcl11a**	B cell CLL/lymphoma 11a (zinc finger protein)	14025	MA -4.5
Bub3	Budding uninhibited by benzimidazoles 3 homolog	12237	E16
Cdc25a	Cell division cycle 25 homolog A (S. pombe)	12530	P0
Dazl	deleted in azoospermia-like	13164	MA -3.1
Etv1	Ets variant gene 1	14009	RA+6.5, E16
Gabpa	GA repeat binding protein, alpha	14390	P0
Greb1	Growth regulation by estrogen in breast cancer 1	268527	E13, E16
Hoxb5**	Homeo box B5	15413	RA-5.1, E16
Id4	Inhibitor of DNA binding 4	15904	MA -5.6
Mcm7	Minichromosome maintenance deficient 7	17220	E16, P0
Nr4a2	Nuclear receptor subfamily 4, group A, member 2	18227	E16
Plagl1	pleiomorphic adenoma gene-like 1	22634	MA +5.3
Serpine2	serine (or cysteine) peptidase inhibitor, clade E, member 2	20720	MR +2.4
Snw1	SNW domain containing 1	66354	E16, P0
Sox21*	SRY-box containing gene 21	223227	MR +2.5
Zfp106	zinc finger protein 106	20402	MR +5.1

All genes listed that do not have an asterisk after the gene symbol are common to our study and the in vivo in mouse ovary study only [7]. Genes denoted by a single asterisk* are common to our study and the human KGN cell line only [6]. Those indicated by ** are common to all three studies. The (-) symbol indicates fold decreased expression. The (+) symbol indicates fold increased expression. MA compares mock (M) transfected cells to activated (A) cells (Foxl2-VP16 transfected). MR compares mock (M) transfected to repressed (R) cells (Foxl2-Mad transfected). RA compares repressed to activated cells. E16 and E13 are mouse embryonic stages day 16 and 13, respectively. P0 is mouse birth stage.

ISSN: 1757-2215