Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter

Table 2 Signaling

Gene Symbol	Name	Entrez Gene ID	Group
Akt1	Thymoma viral proto-oncogene 1	11651	E16
Akt2	Thymoma viral proto-oncogene 2	11652	P0
Ccr2	chemokine (C-C motif) receptor 2	12772	RA +4
Ctla4**	cytotoxic T-lymphocyte-associated protein 4	12477	RA -5.2
Dlg5	Discs, large homolog 5	71228	MA -3.7, RA -3.6
Eda**	ectodysplasin-A	13607	RA -3.9
Fgf8	fibroblast growth factor 8	14179	MR -4.8
Gnrhr***	Gonadotropin releasing hormone receptor	14715	MA -2.5, MR -3.3
Gucy1b3	Guanylate cyclase 1, soluble, beta 3	54195	MR -2.7
Irak1	Interleukin-1 receptor associated kinase 1	16179	E16
Ltk	Leukocyte tyrosine kinase	17005	MA -2.9
Mrgpre**	MAS-related GPR, member E	244238	NA-1.91
Npy1r*	Neuropeptide Y receptor Y1	18166	RA-1.79
Pard3	Par-3(partitioning defective 3)homolog(C. elegans)	263803	E13
Ppp1r1b	Protein phosphatase1, regulatory(inhibitor)subunit 1	19049	P0
Prlr	Prolactin receptor	19116	MA -7.3, MR -7.3
Ptpn6**	Protein tyrosine phosphatase, nonreceptor type 6	15170	MR-2.5, RA+2.1
Reln*	Reelin	19699	MR +7.7
Slit2	Slit homolog 2 (drosophila)	20563	MA -6, MR -11.6
Stc1	Stanniocalcin 1	20855	P0
Stk3	Serine/threonine kinase 3(STE20 homolog, yeast)	56274	E16
Thbd*	Thrombomodulin	21824	NA-2.3, NR-2.5
Tmsb10	Thymosin, beta 10	19240	RA +3.4
Wnt9a	Wingless related MMTV integration site 9a	216795	P0

All genes listed that do not have an asterisk after the gene symbol are common to our study and the in vivo in mouse ovary study only [7]. Genes denoted by a single asterisk* are common to our study and the human KGN cell line only [6]. Those indicated by ** are common to all three studies. The (-) symbol indicates fold decreased expression. The (+) symbol indicates fold increased expression. MA compares mock (M) transfected cells to activated (A) cells (Foxl2-VP16 transfected). MR compares mock (M) transfected to repressed (R) cells (Foxl2-Mad transfected). RA compares repressed to activated cells. E16 and E13 are mouse embryonic stages day 16 and 13, respectively. P0 is mouse birth stage.

ISSN: 1757-2215