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Table 1 Summary of ovarian cancer cell xenograft studies in nude mice.

From: Constitutive activation of BMP signalling abrogates experimental metastasis of OVCA429 cells via reduced cell adhesion

  429T 429T-ALK3QD
  -Dox +Dox -Dox +Dox
n a 14 15 15 14
No. of mice with ascites (%) 6 (42.9) 7 (46.7) 6 (40.0) 4 (28.6)
Mean ascites volume (± SEM) 1.5 (± 0.9) 1.0 (± 0.6) 0.7 (± 0.4) 1.1 (± 0.5)
No. of mice with tumours (%) 10 (71.4) 9 (60.0) 7 (46.7) 6 (42.9)
Mean tumour number (± SEM) 7.5 (± 2.7) 10.4 (± 3.6) 6.2 (± 2.0) 2.2 (± 1.3)
Tumour sites (number of mice)b Pw (5) Pw (8) Pw (3) Pw (4)
  Spl (4) Int (1) Om (6) Lv (1)
  Spl (2) Int (1) Om (8) Lv (4)
  Spl (3) Int (2) Om (6) Lv (4)
  Spl (2) Int (0) Om (1) Lv (1)
  1. a - Two mice died (not due to tumour growth; cause unknown) prior to the experimental endpoint resulting in 14 mice for the 429T -Dox group and 14 mice for the 429T-ALK3QD +Dox group.
  2. b - Number of macroscopic tumour nodules (≥1 mm diameter) was scored. Observed tumour sites (i.e. adherent tumour nodules on tissue/organ surface) were: peritoneal wall (Pw), spleen (Spl), intestine (Int), omentum (Om) and liver (Lv).