| |
429T
|
429T-ALK3QD
|
|---|
| |
-Dox
|
+Dox
|
-Dox
|
+Dox
|
|
n
a
|
14
|
15
|
15
|
14
|
|
No. of mice with ascites (%)
|
6 (42.9)
|
7 (46.7)
|
6 (40.0)
|
4 (28.6)
|
|
Mean ascites volume (± SEM)
|
1.5 (± 0.9)
|
1.0 (± 0.6)
|
0.7 (± 0.4)
|
1.1 (± 0.5)
|
|
No. of mice with tumours (%)
|
10 (71.4)
|
9 (60.0)
|
7 (46.7)
|
6 (42.9)
|
|
Mean tumour number (± SEM)
|
7.5 (± 2.7)
|
10.4 (± 3.6)
|
6.2 (± 2.0)
|
2.2 (± 1.3)
|
|
Tumour sites (number of mice)b
|
Pw (5)
|
Pw (8)
|
Pw (3)
|
Pw (4)
|
| |
Spl (4)
|
Int (1)
|
Om (6)
|
Lv (1)
|
| |
Spl (2)
|
Int (1)
|
Om (8)
|
Lv (4)
|
| |
Spl (3)
|
Int (2)
|
Om (6)
|
Lv (4)
|
| |
Spl (2)
|
Int (0)
|
Om (1)
|
Lv (1)
|
- a - Two mice died (not due to tumour growth; cause unknown) prior to the experimental endpoint resulting in 14 mice for the 429T -Dox group and 14 mice for the 429T-ALK3QD +Dox group.
- b - Number of macroscopic tumour nodules (≥1 mm diameter) was scored. Observed tumour sites (i.e. adherent tumour nodules on tissue/organ surface) were: peritoneal wall (Pw), spleen (Spl), intestine (Int), omentum (Om) and liver (Lv).
