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Table 3 Associations of nuclear survivin expression (continuous variable) with clinical endpoints in the taxane-platinum-treated group* (multivariate Cox's proportional hazard and logistic regression models).

From: Nuclear survivin expression is a positive prognostic factor in taxane-platinum-treated ovarian cancer patients

 

All patients

TP53 (+) group

 

N = 199

N = 110

 

OR/HR [95%CI]

p-value

OR/HR [95%CI]

p-value

High platinum-sensitivity 1

    

Survivin expression

2.09 [1.04,4.17]

0.036

5.04 [1.47,17.18]

0.010

Residual tumour size

    

   0

1.0

 

1.0

 

   ≤ 2 cm

0.17 [0.05,0.54]

0.003

-

 

   > 2 cm

0.09 [0.03,0.31]

0.000

0.21 [0.06,0.73]

0.014

Histological Grade

    

   Grade 2

-

 

1.0

 

   Grade 3

-

 

0.06 [0.00,0.74]

0.028

   Grade 4

-

 

-

 

Disease-free survival

    

Survivin expression

0.67 [0.48,0.91]

0.013

0.44 [0.27,0.69]

0.000

Residual tumour size

    

   0

1.0

 

1.0

 

   ≤ 2 cm

1.66 [0.99,2.78]

0.052

2.33 [1.13,5.26]

0.023

   > 2 cm

1.88 [1.09,2.78]

0.022

3.09 [1.40,6.83]

0.005

Overall survival

    

Survivin expression

-

 

0.64 [0.45,0.89]

0.010

Age (year)

    

   < 53

-

 

1.0

 

   ≥ 53

-

 

1.68 [1.08,2.62]

0.020

FIGO stage

    

   II B, IIC

-

 

-

 

   III A, IIIB

-

 

-

 

   III C

-

 

1.0

 

   IV

-

 

2.76 [1.44,5.27]

0.002

Residual tumour size

    

   0

1.0

 

1.0

 

   ≤ 2 cm

1.23 [1.22,4.07]

0.009

2.23 [1.06,4.67]

0.033

   > 2 cm

3.41 [1.88,6.18]

0.000

2.99 [1.45,6.17]

0.003

Histological Grade

    

   Grade 2

1.0

 

1.0

 

   Grade 3

2.92 [1.45,5.86]

0.003

3.53 [1.45,8.61]

0.005

   Grade 4

2.98 [1.44,6.15]

0.003

2.60 [1.01,6.69]

0.047

  1. 1HPS means the complete remission with DFS longer than 24 months.
  2. * There were no associations with survivin ID score in the TP53(-) group.
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Journal of Ovarian Research

ISSN: 1757-2215

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