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Table 3 Associations of nuclear survivin expression (continuous variable) with clinical endpoints in the taxane-platinum-treated group* (multivariate Cox's proportional hazard and logistic regression models).

From: Nuclear survivin expression is a positive prognostic factor in taxane-platinum-treated ovarian cancer patients

  All patients TP53 (+) group
  N = 199 N = 110
  OR/HR [95%CI] p-value OR/HR [95%CI] p-value
High platinum-sensitivity 1     
Survivin expression 2.09 [1.04,4.17] 0.036 5.04 [1.47,17.18] 0.010
Residual tumour size     
   0 1.0   1.0  
   ≤ 2 cm 0.17 [0.05,0.54] 0.003 -  
   > 2 cm 0.09 [0.03,0.31] 0.000 0.21 [0.06,0.73] 0.014
Histological Grade     
   Grade 2 -   1.0  
   Grade 3 -   0.06 [0.00,0.74] 0.028
   Grade 4 -   -  
Disease-free survival     
Survivin expression 0.67 [0.48,0.91] 0.013 0.44 [0.27,0.69] 0.000
Residual tumour size     
   0 1.0   1.0  
   ≤ 2 cm 1.66 [0.99,2.78] 0.052 2.33 [1.13,5.26] 0.023
   > 2 cm 1.88 [1.09,2.78] 0.022 3.09 [1.40,6.83] 0.005
Overall survival     
Survivin expression -   0.64 [0.45,0.89] 0.010
Age (year)     
   < 53 -   1.0  
   ≥ 53 -   1.68 [1.08,2.62] 0.020
FIGO stage     
   II B, IIC -   -  
   III A, IIIB -   -  
   III C -   1.0  
   IV -   2.76 [1.44,5.27] 0.002
Residual tumour size     
   0 1.0   1.0  
   ≤ 2 cm 1.23 [1.22,4.07] 0.009 2.23 [1.06,4.67] 0.033
   > 2 cm 3.41 [1.88,6.18] 0.000 2.99 [1.45,6.17] 0.003
Histological Grade     
   Grade 2 1.0   1.0  
   Grade 3 2.92 [1.45,5.86] 0.003 3.53 [1.45,8.61] 0.005
   Grade 4 2.98 [1.44,6.15] 0.003 2.60 [1.01,6.69] 0.047
  1. 1HPS means the complete remission with DFS longer than 24 months.
  2. * There were no associations with survivin ID score in the TP53(-) group.