Table 2 Pathway analysis: Pathways/Terms found enriched in the indicated databases for each of the resistance phenotype are shown.
| Â | KEGG (P < 0.001) | GO (P < 0.1) | Reactome (P < 5e-04) |
|---|---|---|---|
Cisp | Leukocyte transendothelial migration (P = 2.7e-06) | cell-substrate adhesion (adjP = 0.0011) | Nephrin interactions (P = 5.1e-05) |
| Â | Focal adhesion (P = 4.76e-06) | response to chemical stimulus (adjP = 0.0012) | Recruitment of Proteins To Vesicles (P = 2.7e-04) |
| Â | ECM-receptor interaction (P = 0.0001) | cellular component movement (adjP = 0.0015) | Activation of PPARA by Fatty Acid (P = 2.8e-04) |
| Â | Ribosome (P = 0.0001) | homeostasis of number of cells (adjP = 0.0028) | Cell-Cell communication (P = 3.3e-04) |
| Â | TGF-beta signaling pathway (P = 0.0001) | Â | Â |
Dox | Proteasome (P = 2.28e-09) | regulation of ubiquitin-protein ligase | Proteasomal cleavage/Cell cycle (P = 3.2e-06) |
| Â | Chemokine signaling pathway (P = 7.16e-06) | (mitosis) (adjP = 1.74e-05) | Platelet activation/degranulation (P = 4.7e-06) |
| Â | Steroid biosynthesis (P = 8.46e-06) | Â | Cholesterol biosynthesis (P = 1.5e-05) |
| Â | Tight junction (P = 8.91e-06) | Â | Â |
| Â | Oocyte meiosis (P = 1.79e-05) | Â | Â |
| Â | Leukocyte transendothelial migration (P = 2.1e-05) | Â | Â |
Tax | Melanogenesis (P = 4.87e-05) | cellular response to oxidative stress (adjP = 0.08) | Platelet activation/degranulation(P = 7.7e-06) |
| Â | Glycolysis/Gluconeogenesis (P = 0.0002) | cellular amino acid metabolism (adjP = 0.0782) | Translation (P = 4.2e-04) |
| Â | Tight junction (P = 0.0002) | hexose metabolic process (adjP = 0.0782) | Â |
| Â | Leukocyte transendothelial migration (P = 0.0005) | translation (adjP = 0.0782) | Â |
| Â | Glutathione metabolism (P = 0.0005) | Â | Â |
| Â | Ribosome (P = 0.0006) | Â | Â |