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Table 2 Summary relative risks for tubal ligation and ovarian cancer by selected characteristics

From: Tubal ligation, hysterectomy and ovarian cancer: A meta-analysis

 

Number of contributing studies

Random-effects

RR (95%CI)

Study design

30 studies

 

 Cohort study

 

0.67 (0.50, 0.90)

 Case-control study

 

0.70 (0.63, 0.75)

 Other study design

 

0.95 (0.63, 1.43)

BRCA status

30 studies

 

 BRCA positive

 

0.64 (0.43, 0.96)

 General population

 

0.70 (0.64, 0.76)

Geographic location

30 studies

 

 US

 

0.68 (0.63, 0.73)

 Non-US

 

0.71 (0.61, 0.82)

Histologic subtype

11 studies

 

 Serous

 

0.75 (0.65,0.88)

 Endometrioid

 

0.45 (0.33,0.61)

 Mucinous

 

0.88 (0.70,1.09)

 Clear cell

 

0.72 (0.55,0.94)

 Other

 

0.80 (0.63,1.01)

Age at tubal ligation

7 studies

 

 <35 years of age

 

0.69 (0.59,0.81)

 35+ years of age

 

0.79 (0.68,0.92)

Years since tubal ligation

6 studies

 

 <10 years

 

0.69 (0.59,0.79)

 10+ years

 

0.68 (0.54,0.87)