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Figure 5 | Journal of Ovarian Research

Figure 5

From: Metformin and phenethyl isothiocyanate combined treatment in vitro is cytotoxic to ovarian cancer cultures

Figure 5

NAC supplementation reverses PEITC cell death. A. The effect of NAC supplementation on control (DMSO vehicle), metformin [5 mM], and PEITC [5 μM] growth inhibitory effects on PA-1 cell line after 24 hours. Metformin is relatively unaffected by the addition of NAC, while PEITC's growth inhibition is significantly reduced. B. The dead cell percent of PA-1 cells treated with control (DMSO vehicle), metformin, or PEITC treatment with and without NAC pre treatment. Metformin alone does not induce high amounts of cell death with or without NAC. PEITC's cell death is strongly reduced to levels similar to control when pretreated with NAC to act as an ROS scavenger. * p < 0.01; n.s. = not significant.

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