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Table 7 Cox regression analyses of overall survival

From: High preoperative blood levels of HE4 predicts poor prognosis in patients with ovarian cancer

    Univariate  
   HR 95% CI p-value
HE4 ≥405 vs. <405 pM 1.9 1.1 - 3.5 0.028
CA125 ≥398 vs. <398 U/ml 2.2 1.2 - 3.8 0.006
Age continous variable 1.02 1.003 - 1.045 0.025
Stage 2-4 vs. 1 3.3 1.6 - 6.9 0.002
Grade 3 vs. 1-2 2.5 1.4 - 4.4 0.002
Residual tumor ≥1 vs. <0-1 cm 2.9 1.8 - 4.8 <0.001
Pre-operative known parameters Multivariate Stepvise Backward*
   HR 95% CI p-value
HE4 ≥405 vs. <405 pM 2.02 1.1 - 3.8 0.02
CA125 ≥398 vs. <398 U/ml    ns
Age continous variable    ns
  1. *Multivariate Stepvise Backward conditional analyses, removal at 0.1 including HE4 and CA125 (dichotomized at median) and age (continous variable).