Cigarette smoke impairs granulosa cell proliferation and oocyte growth after exposure cessation in young Swiss mice: an experimental study

Table 1 Effects of smoke exposure on estrous cycle and ovarian weight

Groups	No. of cycles	Proestrus	Estrus	Metestrus	Diestrus	Ovarian weight
Smoking	2.8 ± 0.25	4.3 ± 0.55	8.8 ± 1.1	3.8 ± 0.68	1.7 ± 0.56	16 ± 2.4
C1	2.8 ± 0.36	4.6 ± 0.58	9.3 ± 0.86	4.9 ± 0.89	3.6 ± 0.71	12 ± 2.3
Interval of 30 days
Ex-smoking	7.8 ± 0.97	16 ± 2.9	18 ± 1.4	14 ± 2.9	2.4 ± 1.3	19 ± 4.4
C2	8.2 ± 0.86	13 ± 2.0	21 ± 3.0	11 ± 1.6	4.4 ± 0.68	20 ± 3.2

Number of cycles and duration of estrous stage (days). Ovarian weight is presented as mg/100 g body weight. Smoking: smoke-exposed animals; C1: age-matched controls for smoking animals; Ex-smoking: animals carried on to cigarette smoke-cessation group; C2: age-matched controls for cigarette smoke-cessation mice. Comparison between groups by the Student’s t-test. Values are mean and SEM. No significant differences between smoking vs. C1 or ex-smoking vs C2.

ISSN: 1757-2215