Skip to main content
Figure 4 | Journal of Ovarian Research

Figure 4

From: Technical challenges and limitations of current mouse models of ovarian cancer

Figure 4

GEM of EOC. Outline of current models of EOC originating from genetic modification of OSE (centre), granulosa cells (bottom left) and oviductal stroma (top left). Phenotypes of OSE carrying single genetic lesions induced by Ad-CMV-Cre (red arrows) or tissue specific expression of oncogenes using the Amhr2 promoter (gray arrows), or expression of Cre from the FSHR promoter (blue arrow) or expression of Cre from the endogenous Amhr2 promoter (green arrows) are indicated. Murine models elicited phenotypes consistent with high grade serous ovarian cancer (HGSC), low grade serous ovarian cancer (LGSC), endometrioid ovarian cancer (EC), leiomyosarcomas (LMS), or the indicated phenotypes. Penetrance of the noted phenotypes, when less than 80%, is expressed as the percentage of animals affected and displayed in brackets. Phenotypes of models are presented in yellow backgrounds, however models based on the activation/inactivation of similar pathways by separate means (eg. Ad-CMV-Cre versus Amhr2-Cre) are shaded with the same colors to facilitate comparison.

Back to article page