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Table 2 Validation gene set, genes with significant changes in one or more of the resistant cell lines according to microarray analysis

From: Distinct genetic alterations occur in ovarian tumor cells selected for combined resistance to carboplatin and docetaxel

Cell line

Gene designation

Protein name

General function

Fold change

P value for fold change

Fluorescence value resistant line

Fluorescence value parent line

A2780CBN

AKR1C3

Aldo-keto reductase family 1 member C3

Catalyzes the conversion of aldehydes and ketones to alcohols

−3.07

4.94 x 10-3

18.75

56.25

 

ANXA1

Annexin A1

Calcium dependent phospholipid binding protein

−104.15

1.38 x 10-4

96.50

9992.50

 

CDH7

Cadherin 7

Cell to cell adhesion glycoprotein

2.08

1.29 x 10-4

67.25

32.75

 

GCLC

Glutamate-cysteine ligase catalytic subunit

Rate limiting enzyme of glutathione synthesis

8.50

5.85 x 10-5

6907.25

815.00

 

GSTO1

Glutathione S-transferase omega 1

Stress response protein, catalyzes addition of glutathione to toxic substrates

2.38

1.07 x 10-3

23166.50

9726.50

 

MT2A

Metallothionein 2A

Heavy metal binding protein

3.69

4.15 x 10-6

4899.50

1266.00

 

PARP9

Poly(ADP)-ribose polymerase family, member 9

Catalyzes addition of ADP-ribose moieties to substrate proteins

9.40

1.95 x 10-3

2523.25

275.25

A2780DXL

CYP1B1

Cytochrome P450 family 1, subfamily B, polypeptide 1

Phase 1 enzyme in drug metabolism

−37.77

2.00 x 10-8

491.50

14858.38

 

LGI1

Leucine-rich glioma inactivated 1

Metastasis regulator

175.85

1.03 x 10-9

5449.25

30.00

 

ABCB1

ATP-binding cassette transport subfamily B, member 1

Multidrug transporter (MDR/TAP family)

33.62

8.22 x 10-11

21065.40

649.60

 

ABCB4

ATP-binding cassette transport subfamily B, member 4

Multidrug transporter (MDR/TAP family)

141.27

5.88 x 10-10

11876.75

84.63

A2780CBNDXL

ABCB1

ATP-binding cassette transport subfamily B, member 1

Multidrug transporter (MDR/TAP family)

35.28

2.43E-03

474.25

13.00

 

ABCB4

ATP-binding cassette transport subfamily B, member 4

Multidrug transporter (MDR/TAP family)

22.70

1.89x10-03

108.75

5.00

 

AKR1C3

Aldo-keto reductase family 1 member C3

Catalyzes the conversion of aldehydes and ketones to alcohols

7.30

2.62 x 10-3

400.75

55.75

 

FLRT3

Fibronectin Leucine-rich Repeat Transmembrane protein 3

Helps regulate cadherin mediated cell adhesion and cell morphogenesis

−115.40

1.79 x 10-3

39.50

4423.25

 

GSTO2

Glutathione S-transferase 2

Stress response protein, catalyzes addition of glutathione to toxic substrates

5.34

2.68 x 10-4

2133.25

400.00

 

CDH7

Cadherin 7

Cell to cell adhesion glycoprotein

68.82

9.24 x 10-4

5223.75

75.70

 

CDH11

Cadherin 11

Cell to cell adhesion glycoprotein

1022.24

1.57 x 10-4

10708.75

10.50