Skip to main content

Table 3 Validation gene set, genes present in all three cell lines according to microarray analysis

From: Distinct genetic alterations occur in ovarian tumor cells selected for combined resistance to carboplatin and docetaxel

Gene designation

Protein name

General function

Cell line

Fold change

P value for fold change

Fluorescence value resistant line

Fluorescence value parent line

LAYN

Layilin

Binds hyaluronan, may play a role in cell adhesion and motility

A2780CBN

−154.83

5.63 x 10-4

88.25

13106.25

   

A2780DXL

−12.95

4.64 x 10-10

75.00

948.50

   

A2780CBNDXL

−145.93

8.16 x 10-4

151.75

14364.25

PRSS7

TMPRSS15, Transmembrane protease, serine 15/enterokinase

Membrane bound enterokinase

A2780CBN

164.34

9.35 x 10-3

1927.75

15.50

   

A2780DXL

84.44

2.24 x 10-8

3028.75

37.63

   

A2780CBNDXL

123.06

1.79 x 10-3

6559.00

60.00