Adrenocortical steroid response to ACTH in different phenotypes of non-obese polycystic ovary syndrome

Table 2 ACTH stimulated hormone levels and their AUC values in patients with PCOS, women with H only and control groups

Parameters	PCOS	H	Control	P
Parameters	(n = 119)	(n = 24)	(n = 39)	(overall)
DHEA ₀	16.7 ± 7.9	20.7 ± 8.9	14.5 ± 5.9	NS
DHEA ₃₀	23.8 ± 6.8	25.2 ± 6.2	21.5 ± 6.3	NS
DHEA ₆₀	25.4 ± 6.3	26.3 ± 6.0	24.6 ± 6.3	NS
17-OHP ₀ (ng/ml)	1.5 ± 0.9^b	1.6 ± 0.7^b	1.1 ± 0.7	<0.01
17-OHP ₃₀ (ng/ml)	3.5 ± 1.5^b	3.4 ± 0.9^c	2.8 ± 1.2	<0.01
17-OHP ₆₀ (ng/ml)	4.1 ± 1.7^b	3.9 ± 0.9^b	3.2 ± 1.1	<0.01
A4 ₀ (ng/ml)	3.1 ± 1.5^a	3.2 ± 1.2^b	2.2 ± 0.9	<0.001
A4 ₃₀ (ng/ml)	4.0 ± 1.8^a	4.0 ± 1.2^b	2.8 ± 0.9	<0.001
A4 ₆₀ (ng/ml)	4.3 ± 1.7^a	4.1 ± 1.2^b	3.1 ± 0.9	<0.001
F ₀ (μg/dl)	13.9 ± 5.8	15.9 ± 7.6	14.0 ± 5.4	NS
F ₃₀ (μg/dl)	26.5 ± 5.0	26.2 ± 5.4	25.9 ± 4.5	NS
F ₆₀ (μg/dl)	30.9 ± 6.1	30.8 ± 6.4	30.6 ± 5.0	NS
AUC _DHEA (ng/ml × 60 min)	1338 ± 375	1459 ± 375	1227 ± 351	NS
AUC _17-OHP (ng/ml × 60 min)	190 ± 80^b	183 ± 44^b	148 ± 60	<0.01
AUC _A4 (ng/ml × 60 min)	232 ± 99^a	229 ± 69^c	165 ± 53	<0.001
AUC _F (μg/dl × 60 min)	1471 ± 303	1487 ± 361	1446 ± 258	NS

Results are expressed as mean ± SD. NS not significant, AUC area under the curve, DHEA dehydroepiandrosterone, 17-OHP 17-hydroxyprogesterone, A4 androstenedione, F cortisol.
^a P <0.001 vs. Control.
^b P <0.01 vs. Control.
^c P <0.05 vs. Control.

ISSN: 1757-2215