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Table 2 ACTH stimulated hormone levels and their AUC values in patients with PCOS, women with H only and control groups

From: Adrenocortical steroid response to ACTH in different phenotypes of non-obese polycystic ovary syndrome

Parameters PCOS H Control P
(n = 119) (n = 24) (n = 39) (overall)
DHEA 0 16.7 ± 7.9 20.7 ± 8.9 14.5 ± 5.9 NS
DHEA 30 23.8 ± 6.8 25.2 ± 6.2 21.5 ± 6.3 NS
DHEA 60 25.4 ± 6.3 26.3 ± 6.0 24.6 ± 6.3 NS
17-OHP 0 (ng/ml) 1.5 ± 0.9b 1.6 ± 0.7b 1.1 ± 0.7 <0.01
17-OHP 30 (ng/ml) 3.5 ± 1.5b 3.4 ± 0.9c 2.8 ± 1.2 <0.01
17-OHP 60 (ng/ml) 4.1 ± 1.7b 3.9 ± 0.9b 3.2 ± 1.1 <0.01
A4 0 (ng/ml) 3.1 ± 1.5a 3.2 ± 1.2b 2.2 ± 0.9 <0.001
A4 30 (ng/ml) 4.0 ± 1.8a 4.0 ± 1.2b 2.8 ± 0.9 <0.001
A4 60 (ng/ml) 4.3 ± 1.7a 4.1 ± 1.2b 3.1 ± 0.9 <0.001
F 0 (μg/dl) 13.9 ± 5.8 15.9 ± 7.6 14.0 ± 5.4 NS
F 30 (μg/dl) 26.5 ± 5.0 26.2 ± 5.4 25.9 ± 4.5 NS
F 60 (μg/dl) 30.9 ± 6.1 30.8 ± 6.4 30.6 ± 5.0 NS
AUC DHEA (ng/ml × 60 min) 1338 ± 375 1459 ± 375 1227 ± 351 NS
AUC 17-OHP (ng/ml × 60 min) 190 ± 80b 183 ± 44b 148 ± 60 <0.01
AUC A4 (ng/ml × 60 min) 232 ± 99a 229 ± 69c 165 ± 53 <0.001
AUC F (μg/dl × 60 min) 1471 ± 303 1487 ± 361 1446 ± 258 NS
  1. Results are expressed as mean ± SD. NS not significant, AUC area under the curve, DHEA dehydroepiandrosterone, 17-OHP 17-hydroxyprogesterone, A4 androstenedione, F cortisol.
  2. a P <0.001 vs. Control.
  3. b P <0.01 vs. Control.
  4. c P <0.05 vs. Control.