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Table 1 miRNAs: functions and targets in ovarian cancer

From: Current status and implications of microRNAs in ovarian cancer diagnosis and therapy

microRNAs Function Targets Reference
miR-200 family Tumor suppressor ZEB1,ZEB2,β tubulin III [31, 42, 45, 47, 48, 5159, 111, 112]
  (Loss of EMT)   
Let-7 family Tumor suppressor KRAS,HRAS,C-MYC,HMGA-2,CyclinA,D1,D2,D3,CDC25,CDK6 [47, 6881, 110, 113, 116, 117]
  (Chemosensitization)   
miR-34a/b/c Tumor suppressor c-myc,CDK6,Notch-1,MET,E2f3,Bcl2,cyclinD1 [82, 119]
  (Reduced invasion/migration/proliferation)   
miR-100 Tumor suppressor mTOR, PLK-1 [8385]
  (Increased sensitivity to rapamycin analogs)   
miR-31 Tumor suppressor E2F2, STK40 [86]
  (Increased apoptosis)   
miR-214/199a* Oncogenic PTEN [51, 8791, 93, 112]
  (Chemoresistance)   
miR-376c Oncogenic ALK7 [21, 98]
  (Chemoresistance)   
miR-93 Oncogenic PTEN [100102]
  (Chemoresistance)   
miR-21 Oncogenic PTEN [47, 51, 104107, 112]
  (Chemoresistance)   
  1. miRNAs in ovarian carcinoma can either be oncogenic or tumor suppressor. Tumor suppressor miRNAs suppress oncogenes resulting in either loss of EMT (Epithelial Mesenchymal Transition), chemosensitization or tumor suppression. Whereas, oncogenic miRNAs target tumor suppressor genes leading to chemo resistance and reduced survival.