From: Current status and implications of microRNAs in ovarian cancer diagnosis and therapy
microRNAs | Function | Targets | Reference |
---|---|---|---|
miR-200 family | Tumor suppressor | ZEB1,ZEB2,β tubulin III | [31, 42, 45, 47, 48, 51–59, 111, 112] |
(Loss of EMT) | |||
Let-7 family | Tumor suppressor | KRAS,HRAS,C-MYC,HMGA-2,CyclinA,D1,D2,D3,CDC25,CDK6 | [47, 68–81, 110, 113, 116, 117] |
(Chemosensitization) | |||
miR-34a/b/c | Tumor suppressor | c-myc,CDK6,Notch-1,MET,E2f3,Bcl2,cyclinD1 | [82, 119] |
(Reduced invasion/migration/proliferation) | |||
miR-100 | Tumor suppressor | mTOR, PLK-1 | [83–85] |
(Increased sensitivity to rapamycin analogs) | |||
miR-31 | Tumor suppressor | E2F2, STK40 | [86] |
(Increased apoptosis) | |||
miR-214/199a* | Oncogenic | PTEN | [51, 87–91, 93, 112] |
(Chemoresistance) | |||
miR-376c | Oncogenic | ALK7 | [21, 98] |
(Chemoresistance) | |||
miR-93 | Oncogenic | PTEN | [100–102] |
(Chemoresistance) | |||
miR-21 | Oncogenic | PTEN | [47, 51, 104–107, 112] |
(Chemoresistance) |