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Table 1 miRNAs: functions and targets in ovarian cancer

From: Current status and implications of microRNAs in ovarian cancer diagnosis and therapy

microRNAs

Function

Targets

Reference

miR-200 family

Tumor suppressor

ZEB1,ZEB2,β tubulin III

[31, 42, 45, 47, 48, 51–59, 111, 112]

 

(Loss of EMT)

  

Let-7 family

Tumor suppressor

KRAS,HRAS,C-MYC,HMGA-2,CyclinA,D1,D2,D3,CDC25,CDK6

[47, 68–81, 110, 113, 116, 117]

 

(Chemosensitization)

  

miR-34a/b/c

Tumor suppressor

c-myc,CDK6,Notch-1,MET,E2f3,Bcl2,cyclinD1

[82, 119]

 

(Reduced invasion/migration/proliferation)

  

miR-100

Tumor suppressor

mTOR, PLK-1

[83–85]

 

(Increased sensitivity to rapamycin analogs)

  

miR-31

Tumor suppressor

E2F2, STK40

[86]

 

(Increased apoptosis)

  

miR-214/199a*

Oncogenic

PTEN

[51, 87–91, 93, 112]

 

(Chemoresistance)

  

miR-376c

Oncogenic

ALK7

[21, 98]

 

(Chemoresistance)

  

miR-93

Oncogenic

PTEN

[100–102]

 

(Chemoresistance)

  

miR-21

Oncogenic

PTEN

[47, 51, 104–107, 112]

 

(Chemoresistance)

  
  1. miRNAs in ovarian carcinoma can either be oncogenic or tumor suppressor. Tumor suppressor miRNAs suppress oncogenes resulting in either loss of EMT (Epithelial Mesenchymal Transition), chemosensitization or tumor suppression. Whereas, oncogenic miRNAs target tumor suppressor genes leading to chemo resistance and reduced survival.