From: Current status and implications of microRNAs in ovarian cancer diagnosis and therapy
microRNAs | Function | Targets | Reference |
---|---|---|---|
miR-200 family | Tumor suppressor | ZEB1,ZEB2,β tubulin III | |
 | (Loss of EMT) |  |  |
Let-7 family | Tumor suppressor | KRAS,HRAS,C-MYC,HMGA-2,CyclinA,D1,D2,D3,CDC25,CDK6 | |
 | (Chemosensitization) |  |  |
miR-34a/b/c | Tumor suppressor | c-myc,CDK6,Notch-1,MET,E2f3,Bcl2,cyclinD1 | |
 | (Reduced invasion/migration/proliferation) |  |  |
miR-100 | Tumor suppressor | mTOR, PLK-1 | |
 | (Increased sensitivity to rapamycin analogs) |  |  |
miR-31 | Tumor suppressor | E2F2, STK40 | [86] |
 | (Increased apoptosis) |  |  |
miR-214/199a* | Oncogenic | PTEN | |
 | (Chemoresistance) |  |  |
miR-376c | Oncogenic | ALK7 | |
 | (Chemoresistance) |  |  |
miR-93 | Oncogenic | PTEN | |
 | (Chemoresistance) |  |  |
miR-21 | Oncogenic | PTEN | |
 | (Chemoresistance) |  |  |