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Table 2 Relative risks of death from ovarian cancer and overall death according to DACH2 expression in all patients and patients with serous carcinoma.

From: Discovery of dachshund 2 protein as a novel biomarker of poor prognosis in epithelial ovarian cancer

 

Ovarian cancer specific survival

Overall survival

 

HR(95%CI)

p-value

n(events)

HR(95%CI)

p-value

n(events)

All

 

Univariable

  

Univariable

 

DACH2 low

1,00

0.048

60

1,00

0.022

60

DACH2 high

1.54(1.00-2.35)

 

83

1.63(1.07-2.47)

 

83

  

Multivariable

  

Multivariable

 

DACH2 low

1,00

0.182

55

1,00

0.088

55

DACH2 high

1.36(0.87-2.12)

 

76

1.57(0.95-2.28)

 

76

Serous carcinoma

 

Univariable

  

Univariable

 

DACH2 low

1,00

0.010

28

1,00

0.005

28

DACH2 high

2.21(1.21-4.04)

 

56

2.34(1.23-4.26)

 

56

  

Multivariable

  

Multivariable

 

DACH2 low

1,00

0.035

25

1,00

0.022

25

DACH2 high

2.01(1.05-3.85)

 

51

2.13(1.12-4.08)

 

51

  1. Cox uni- and multivariable analysis of relative risks of death from ovarian cancer and overall death according to DACH2 expression in all patients and patients with serous carcinoma. HR = Hazard ratio. The categories of staining were determined according to the nuclear score (NS), e.g. a multiplier of fraction and intensity, whereby low expression = NS < = 3 and high expression = NS > 3. Multivariate analysis included adjustment for differentiation grade (low-intermediate vs high) and clinical stage (1-2 vs 3 and 4).