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Table 1 Peritoneal Metastasis and Inhibition

From: Production of IL1-beta by ovarian cancer cells induces mesothelial cell beta1-integrin expression facilitating peritoneal dissemination

A) Peritoneal metastasis after intraperitoneal transplantation of FOC3 and MFOC3

Cell Line

Number of Mice

Number of Mice with Metastasis (%)

FOC3

10

0(0)

MFOC3

16

13 (81.3) *

  

*FOC3 vs MFOC3: p < 0.01 (χ2 test)

B) Inhibition of Peritoneal metastasis in MFOC3 cells by anti-IL-1 β and anti- integrin β1

Antibody

Number of Mice

Number of Mice with Metastasis (%)

control

10

8 (80) a

IL-1β

10

7 (70) b

Integrin β1

10

2 (20) c

  

a vs b: non significant;

  

a vs c: p < 0.01 (χ2 test)