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Figure 6 | Journal of Ovarian Research

Figure 6

From: Insulin and insulin-like growth factor signaling increases proliferation and hyperplasia of the ovarian surface epithelium and decreases follicular integrity through upregulation of the PI3-kinase pathway

Figure 6

Insulin- and IGF-induced OSE hyperplasia and proliferation requires PI3K signaling. Organoids were cultured 7d in media containing the PI3K inhibitor 10 μM LY294002, 10 μM LY294002 plus 5 μg/ml insulin, or 10 μM LY294002 plus 5 μg/ml IGF-I. Tissues were stained for expression of CK8 and BrdU (A) and the percentage of proliferating OSE was quantified (B). All images are 400X. Data shown represent SEM. Statistical differences (P<0.05) are between groups labeled a and b.

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Journal of Ovarian Research

ISSN: 1757-2215

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