Table 2 Relapse prediction using the rising values of serum CA-125 levels from nadir to ≥ 1.68 × nadir or to ≥ 70 U/ml
Variable | 1.68 × Nadir | 70 U/ml | ||
|---|---|---|---|---|
CT | MRI | PET–CT | ||
True positive, no. of patients | 170 | 6 | 14 | 90 |
False positive, no. of patients | 11 | 0 | 2 | 2 |
True negative, no. of patients | 115 | 6 | 2 | 124 |
False negative, no. of patients | 74 | 3 | 8 | 154 |
Sensitivity, % | 69.7 | 66.6 | 63.6 | 36.9 |
Specificity, % | 88.5 | 100 | 50.0 | 98.4 |
Positive predictive value, % | 93.9 | 100 | 87.5 | 97.8 |
Negative predictive value, % | 60.8 | 66.6 | 20.0 | 44.6 |
Median lead-time, days (range) | 31 (1–391) | 16 (1–250) | ||
Median lead-time from 2 × nadir to 70 U/ml, days (range) | 22 (0–46) | |||