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Table 2 Relapse prediction using the rising values of serum CA-125 levels from nadir to ≥ 1.68 × nadir or to ≥ 70 U/ml

From: CA-125–indicated asymptomatic relapse confers survival benefit to ovarian cancer patients who underwent secondary cytoreduction surgery

Variable 1.68 × Nadir 70 U/ml
CT MRI PET–CT
True positive, no. of patients 170 6 14 90
False positive, no. of patients 11 0 2 2
True negative, no. of patients 115 6 2 124
False negative, no. of patients 74 3 8 154
Sensitivity, % 69.7 66.6 63.6 36.9
Specificity, % 88.5 100 50.0 98.4
Positive predictive value, % 93.9 100 87.5 97.8
Negative predictive value, % 60.8 66.6 20.0 44.6
Median lead-time, days (range) 31 (1–391) 16 (1–250)
Median lead-time from 2 × nadir to 70 U/ml, days (range) 22 (0–46)
  1. Abbreviations: CT, computed tomography; MRI, magnetic resonance imaging; PET, positron emission tomography.