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Table 4 Baseline QoL measures and associated HRs for death

From: Longitudinal health-related quality of life assessment: implications for prognosis in ovarian cancer

Baseline variable QoL score mean (SD) Univariate Multivariate
HR (95%CI) P HR (95% CI) P
General quality of life      
Global 59.7 (24.2) 1.05 (0.93 – 1.17) 0.45 1.07 (0.94 – 1.19) 0.29
General function      
Physical 76.6 (22.8) 0.93 (0.79 – 1.06) 0.27 1.07 (0.80 – 1.35) 0.63
Role 66.9 (31.5) 0.99 (0.90 – 1.07) 0.76 0.91(0.75 – 1.08) 0.30
Emotional 70.1 (23.8) 1.02(0.90 – 1.14) 0.76 1.07 (0.88 – 1.27) 0.48
Cognitive 78.3 (22.8) 0.97 (0.85 – 1.09) 0.66 0.91 (0.71 – 1.11) 0.38
Social 66.5 (32.9) 1.02 (0.93 – 1.11) 0.71 1.02 (0.88 – 1.17) 0.76
General symptom      
Fatigue 40.0 (28.4) 1.02 (0.92 – 1.12) 0.76 1.11 (0.87 – 1.35) 0.38
Nausea/vomiting 13.1 (22.4) 1.10 (0.94 – 1.25) 0.21 1.16 (0.97 – 1.35) 0.10
Pain 28.4 (28.5) 1.02 (0.91 – 1.13) 0.70 0.99 (0.83 – 1.15) 0.90
Dyspnea 21.4 (27.9) 1.09 (0.99 – 1.18) 0.07 1.10 (0.92 – 1.27) 0.28
Insomnia 38.4 (34.0) 0.98 (0.89 – 1.07) 0.67 0.90 (0.78 – 1.02) 0.09
Appetite loss 20.6 (29.1) 0.98 (0.89 – 1.07) 0.65 0.90 (0.75 – 1.05) 0.19
Constipation 22.1 (28.9) 0.97 (0.87 – 1.07) 0.55 0.94 (0.80 – 1.08) 0.38
Diarrhea 15.0 (24.5) 0.96 (0.83 – 1.09) 0.58 0.88 (0.72 – 1.04) 0.14
Financial 33.5 (32.7) 0.98 (0.89 – 1.06) 0.58 0.98 (0.86 – 1.09) 0.68
  1. • HRs correspond to a 10-point increment for QoL scores.
  2. • 2 sets of multivariate models were constructed: one for global QoL and other for all general function and symptom variables combined.
  3. • Multivariate model (for general function and symptom variables combined) adjusted for prior treatment history and all baseline QoL variables.
  4. • Multivariate model for global QoL adjusted for prior treatment history.