Longitudinal health-related quality of life assessment: implications for prognosis in ovarian cancer

Table 4 Baseline QoL measures and associated HRs for death

Baseline variable	QoL score mean (SD)	Univariate		Multivariate
Baseline variable	QoL score mean (SD)	HR (95%CI)	P	HR (95% CI)	P
General quality of life
Global	59.7 (24.2)	1.05 (0.93 – 1.17)	0.45	1.07 (0.94 – 1.19)	0.29
General function
Physical	76.6 (22.8)	0.93 (0.79 – 1.06)	0.27	1.07 (0.80 – 1.35)	0.63
Role	66.9 (31.5)	0.99 (0.90 – 1.07)	0.76	0.91(0.75 – 1.08)	0.30
Emotional	70.1 (23.8)	1.02(0.90 – 1.14)	0.76	1.07 (0.88 – 1.27)	0.48
Cognitive	78.3 (22.8)	0.97 (0.85 – 1.09)	0.66	0.91 (0.71 – 1.11)	0.38
Social	66.5 (32.9)	1.02 (0.93 – 1.11)	0.71	1.02 (0.88 – 1.17)	0.76
General symptom
Fatigue	40.0 (28.4)	1.02 (0.92 – 1.12)	0.76	1.11 (0.87 – 1.35)	0.38
Nausea/vomiting	13.1 (22.4)	1.10 (0.94 – 1.25)	0.21	1.16 (0.97 – 1.35)	0.10
Pain	28.4 (28.5)	1.02 (0.91 – 1.13)	0.70	0.99 (0.83 – 1.15)	0.90
Dyspnea	21.4 (27.9)	1.09 (0.99 – 1.18)	0.07	1.10 (0.92 – 1.27)	0.28
Insomnia	38.4 (34.0)	0.98 (0.89 – 1.07)	0.67	0.90 (0.78 – 1.02)	0.09
Appetite loss	20.6 (29.1)	0.98 (0.89 – 1.07)	0.65	0.90 (0.75 – 1.05)	0.19
Constipation	22.1 (28.9)	0.97 (0.87 – 1.07)	0.55	0.94 (0.80 – 1.08)	0.38
Diarrhea	15.0 (24.5)	0.96 (0.83 – 1.09)	0.58	0.88 (0.72 – 1.04)	0.14
Financial	33.5 (32.7)	0.98 (0.89 – 1.06)	0.58	0.98 (0.86 – 1.09)	0.68

• HRs correspond to a 10-point increment for QoL scores.
• 2 sets of multivariate models were constructed: one for global QoL and other for all general function and symptom variables combined.
• Multivariate model (for general function and symptom variables combined) adjusted for prior treatment history and all baseline QoL variables.
• Multivariate model for global QoL adjusted for prior treatment history.

ISSN: 1757-2215