Figure 3
Effect of AT 1 -AA on migration of OVCAR3 cells. AT1-AA increased migration in a dose-dependent manner (top panel). Relative to the control (A), cell migration by AT1-AA was significantly enhanced (B), which is comparable to the level found in Ang II (C). Enhancement of migration by AT1-AA was blocked either by AT1-AA-ECII (D) or losartan (E). Values are mean ± SE. n = 3 for each group. *p < 0.05 vs. saline control (Nor); †P < 0.05 vs. AT1-AA and Ang II. HPF = high power field (x 400).