Figure 8

Box plots of serum levels of A) FRA, C) MSLN, E) MPF G) CA125 and I) HE4 in healthy controls and serous ovarian cancer patients by stage. Boxes indicate the 25th to 75th percentiles. The horizontal lines within the boxes are the median serum levels and the whiskers indicate the minimum and maximum values. P-values indicate statistical significance of differences between each group and healthy controls. ROC curves showing the performance of B) FRA, D) MSLN, F) MPF, H) CA125 and J) HE4 serum biomarkers in discrimination of healthy controls and serous ovarian cancer patients by stage (I, orange line; II, green line; III, red line; IV, blue line).