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Figure 1 | Journal of Ovarian Research

Figure 1

From: Sensitization of ovarian carcinoma cells to Bcl-xL-targeting strategies through indirect modulation of Mcl-1 activity by MR22388, a molecule of the tripentone family

Figure 1

MR22388 exerts a cytostatic and cytotoxic effect on cisplatin-resistant cell lines. Exponentially growing SKOV3 and IGROV1-R10 cells were treated with MR22388 at 10, 100 and 1000 nM. [A] Percentages of cell viability, assessed by trypan blue exclusion test after 24, 48 and 72 h exposure to MR22388, as compared to the initial number of viable cells in the flask. [B] Real time analysis of cellular activity of MR22388 obtained using the xCELLigence system. Cells were grown for 24 h, then treated with MR22388 (10, 100 and 1000 nM). Cell index was recorded every 2 h. The results are the mean of three replicates. [C] DNA content histograms and cellular morphologies, assessed 72 h after the beginning of the MR22388 exposure.

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