Body mass index-stratified analysis of osteocalcin (OC) in 52 cases and 26 age-matched controls. (upper panel). Higher under-carboxylated (uc) OC concentration was evidenced in lean (p = 0.037) PCOS patients (n = 17, black bar) vs. controls (n = 13, blue bar) but not overweight and obese (p = 0.490) PCOS patients (n = 35, black bar) vs. controls (n = 13, blue bar), even in multivariate analysis (p = 0.001 in lean and p = 0.456 in overweight and obese). (lower panel). Statistical analysis retrieved no differences in serum OC in either lean (p = 0.146) or overweight and obese (p = 0.569) women with PCOS (black bars) and controls (blue bars). Multivariate analysis had no effect on end results (p = 0.535 in lean and p = 0.888 in overweight and obese).