Table 3 Association between the Tyr113His mEH polymorphism and risk of ovarian cancer of different histological subtypes
From: mEH Tyr113His polymorphism and the risk of ovarian cancer development
Genotype comparison | OR [95% CI] | Z (P value) | Heterogeneity of study design | Analysis model | ||
|---|---|---|---|---|---|---|
χ 2 | df (P value) | I 2 | ||||
Serous (441 cases, 718 controls) | ||||||
C-allele vs. T-allele | 0.87 [0.72, 1.06] | 1.39 (0.16) | 4.25 | 2 (0.12) | 53% | Fixed |
CC vs. TT | 0.89 [0.60, 1.33] | 0.56 (0.58) | 1.85 | 2 (0.40) | 0% | Fixed |
CC vs. TT + TC | 0.85 [0.59, 1.23] | 0.87 (0.38) | 1.13 | 2 (0.57) | 0% | Fixed |
TT vs. CC + TC | 0.99 [0.78, 1.27] | 0.06 (0.95) | 1.09 | 2 (0.58) | 0% | Fixed |
Endometrioid and clear cell (212 cases, 718 controls) | ||||||
C-allele vs. T-allele | 0.54 [0.42, 0.70] | 4.67 (<0.001) | 0.30 | 2 (0.86) | 0% | Fixed |
CC vs. TT | 1.30 [0.56, 3.01] | 0.62 (0.54) | 7.36 | 2 (0.03) | 73% | Random |
CC vs. TT + TC | 1.33 [0.65, 2.73] | 0.78 (0.43) | 6.26 | 2 (0.04) | 68% | Random |
TT vs. CC + TC | 0.88 [0.65, 1.20] | 0.78 (0.43) | 4.03 | 2 (0.13) | 50% | Fixed |
Mucinous (70 cases, 544 controls) | ||||||
C-allele vs. T-allele | 1.08 [0.74, 1.58] | 0.40 (0.69) | 0.94 | 1 (0.33) | 0% | Fixed |
CC vs. TT | 23.53 [9.40, 58.93] | 6.74 (<0.001) | 0.41 | 1 (0.52) | 0% | Fixed |
CC vs. TT + TC | 0.77 [0.32, 1.86] | 0.57 (0.57) | 0.13 | 1 (0.72) | 0% | Fixed |
TT vs. CC + TC | 0.79 [0.48, 1.31] | 0.90 (0.37) | 0.98 | 1 (0.32) | 0% | Fixed |