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Table 3 Association between the Tyr113His mEH polymorphism and risk of ovarian cancer of different histological subtypes

From: mEH Tyr113His polymorphism and the risk of ovarian cancer development

Genotype comparison OR [95% CI] Z (P value) Heterogeneity of study design Analysis model
χ 2 df (P value) I 2
Serous (441 cases, 718 controls)
C-allele vs. T-allele 0.87 [0.72, 1.06] 1.39 (0.16) 4.25 2 (0.12) 53% Fixed
CC vs. TT 0.89 [0.60, 1.33] 0.56 (0.58) 1.85 2 (0.40) 0% Fixed
CC vs. TT + TC 0.85 [0.59, 1.23] 0.87 (0.38) 1.13 2 (0.57) 0% Fixed
TT vs. CC + TC 0.99 [0.78, 1.27] 0.06 (0.95) 1.09 2 (0.58) 0% Fixed
Endometrioid and clear cell (212 cases, 718 controls)
C-allele vs. T-allele 0.54 [0.42, 0.70] 4.67 (<0.001) 0.30 2 (0.86) 0% Fixed
CC vs. TT 1.30 [0.56, 3.01] 0.62 (0.54) 7.36 2 (0.03) 73% Random
CC vs. TT + TC 1.33 [0.65, 2.73] 0.78 (0.43) 6.26 2 (0.04) 68% Random
TT vs. CC + TC 0.88 [0.65, 1.20] 0.78 (0.43) 4.03 2 (0.13) 50% Fixed
Mucinous (70 cases, 544 controls)
C-allele vs. T-allele 1.08 [0.74, 1.58] 0.40 (0.69) 0.94 1 (0.33) 0% Fixed
CC vs. TT 23.53 [9.40, 58.93] 6.74 (<0.001) 0.41 1 (0.52) 0% Fixed
CC vs. TT + TC 0.77 [0.32, 1.86] 0.57 (0.57) 0.13 1 (0.72) 0% Fixed
TT vs. CC + TC 0.79 [0.48, 1.31] 0.90 (0.37) 0.98 1 (0.32) 0% Fixed