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Table 3 Sensitivity, specificity, PPV and NPV of controls and malignant vs benign cases for each marker

From: The use of HE4, CA125 and CA72-4 biomarkers for differential diagnosis between ovarian endometrioma and epithelial ovarian cancer

  CA125 HE4 CA72-4
Sensitivity % 90 87 67
Specificity % 70 100 96
PPV 51 100 84
NPV 95 96 89
  1. Cut-off levels: CA125 = 35 U/mL; HE4 = 150 pmol/L; CA72-4 =3.8 U/mL.