Table 4 The diagnostic criteria of the ROC curve for VEGF in combination with HE4 and CA125 in ovarian cancer patients

I stage

AUC

0.7984*

0.7284*

0.7652*

0.8632*

0.8784*

0.8327*

0.8980*

SE

0.0562

0.0708

0.0416

0.0508

0.0475

0.0538

0.0433

95% C.I.

0.688-0.909

0.590-0.867

0.691-0.794

0.764-0.963

0.785-0.971

0.727-0.938

0.813-0.83

p AUC = 0.5

<0.001

0.0013

0.0005

<0.001

<0.001

<0.001

<0.001

II stage

AUC

0.7231*

0.7646*

0.8652*

0.8592*

0.8587*

0.9207*

0.9207*

SE

0.0647

0.0562

0.0389

0.0421

0.0510

0.0314

0.0294

95% C.I.

0.596-0.850

0.654-0.875

0.814-0.967

0.777-0.942

0.759-0.959

0.859-0.982

0.863-0.978

p AUC = 0.5

0.0006

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

III stage

AUC

0.9012*

0.9256*

0.9112*

0.9680*

0.9665*

0.9763*

0.9837*

SE

0.0428

0.0291

0.0428

0.0167

0.0221

0.0302

0.0120

95% C.I.

0.817-0.985

0.869-0.983

0.827-0.995

0.935-1.001

0.923-1.010

0.902-1.020

0.960-1.007

p AUC = 0.5

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

IV stage

AUC

0.7168*

0.9124*

0.9472*

0.9240*

0.9494*

0.9420*

0.9600*

SE

0.0722

0.0428

0.0260

0.0382

0.0315

0.0353

0.0281

95% C.I.

0.575-0.858

0.829-0.996

0.896-0.998

0.849-0.999

0.888-1.011

0.873-1.011

0.905-1.015

p AUC = 0.5

0.0027

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

Total group

AUC

0.7843*

0.8321*

0.9276*

0.9032*

0.9127*

0.9180*

0.9404*

SE

0.0376

0.0321

0.0221

0.0239

0.0250

0.0223

0.0187

95% C.I.

0.711-0.858

0.769-0.895

0.884-0.971

0.856-0.950

0.864-0.962

0.874-0.962

0.904-0.977

p AUC = 0.5

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

Serous epithelial

AUC

0.7522*

0.8720*

0.9047*

0.9124*

0.9009*

0.9391*

0.9395*

SE

0.0482

0.0347

0.0301

0.0278

0.0312

0.0233

0.0230

95% C.I.

0.658-0.847

0.804-0.964

0.846-0.964

0.858-0.967

0.840-0.962

0.893-0.985

0.894-0.985

p AUC = 0.5

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

Endome-trioid epithelial

AUC

0.8226*

0.7843*

0.9128*

0.8922*

0.9268*

0.8926*

0.9414*

SE

0.0438

0.0467

0.0305

0.0323

0.0299

0.0330

0.0228

95% C.I.

0.737-0.908

0.693-0.876

0.853-0.973

0.829-0.955

0.868-0.985

0.828-0.957

0.897-0.986

p AUC = 0.5

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001