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Table 4 The diagnostic criteria of the ROC curve for VEGF in combination with HE4 and CA125 in ovarian cancer patients

From: The plasma concentration of VEGF, HE4 and CA125 as a new biomarkers panel in different stages and sub-types of epithelial ovarian tumors

Epithelial ovarian cancer The ROC criteria VEGF HE4 CA125 VEGF + HE4 VEGF + CA 125 HE4 + CA125 VEGF + HE4+ CA125
I stage AUC 0.7984* 0.7284* 0.7652* 0.8632* 0.8784* 0.8327* 0.8980*
SE 0.0562 0.0708 0.0416 0.0508 0.0475 0.0538 0.0433
95% C.I. 0.688-0.909 0.590-0.867 0.691-0.794 0.764-0.963 0.785-0.971 0.727-0.938 0.813-0.83
  p AUC = 0.5 <0.001 0.0013 0.0005 <0.001 <0.001 <0.001 <0.001
II stage AUC 0.7231* 0.7646* 0.8652* 0.8592* 0.8587* 0.9207* 0.9207*
SE 0.0647 0.0562 0.0389 0.0421 0.0510 0.0314 0.0294
95% C.I. 0.596-0.850 0.654-0.875 0.814-0.967 0.777-0.942 0.759-0.959 0.859-0.982 0.863-0.978
  p AUC = 0.5 0.0006 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001
III stage AUC 0.9012* 0.9256* 0.9112* 0.9680* 0.9665* 0.9763* 0.9837*
SE 0.0428 0.0291 0.0428 0.0167 0.0221 0.0302 0.0120
95% C.I. 0.817-0.985 0.869-0.983 0.827-0.995 0.935-1.001 0.923-1.010 0.902-1.020 0.960-1.007
  p AUC = 0.5 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001
IV stage AUC 0.7168* 0.9124* 0.9472* 0.9240* 0.9494* 0.9420* 0.9600*
SE 0.0722 0.0428 0.0260 0.0382 0.0315 0.0353 0.0281
95% C.I. 0.575-0.858 0.829-0.996 0.896-0.998 0.849-0.999 0.888-1.011 0.873-1.011 0.905-1.015
  p AUC = 0.5 0.0027 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001
Total group AUC 0.7843* 0.8321* 0.9276* 0.9032* 0.9127* 0.9180* 0.9404*
SE 0.0376 0.0321 0.0221 0.0239 0.0250 0.0223 0.0187
95% C.I. 0.711-0.858 0.769-0.895 0.884-0.971 0.856-0.950 0.864-0.962 0.874-0.962 0.904-0.977
  p AUC = 0.5 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001
Serous epithelial AUC 0.7522* 0.8720* 0.9047* 0.9124* 0.9009* 0.9391* 0.9395*
SE 0.0482 0.0347 0.0301 0.0278 0.0312 0.0233 0.0230
95% C.I. 0.658-0.847 0.804-0.964 0.846-0.964 0.858-0.967 0.840-0.962 0.893-0.985 0.894-0.985
  p AUC = 0.5 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001
Endome-trioid epithelial AUC 0.8226* 0.7843* 0.9128* 0.8922* 0.9268* 0.8926* 0.9414*
SE 0.0438 0.0467 0.0305 0.0323 0.0299 0.0330 0.0228
95% C.I. 0.737-0.908 0.693-0.876 0.853-0.973 0.829-0.955 0.868-0.985 0.828-0.957 0.897-0.986
  p AUC = 0.5 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001 <0.001
  1. C.I. confidence intervals of AUC.
  2. * statistically significant when comparing tested parameters AUC’s with 0.5 AUC’s.