Figure 1From: PRIMA-1 increases cisplatin sensitivity in chemoresistant ovarian cancer cells with p53 mutation: a requirement for Akt down-regulation The effect of different concentration of PRIMA-1 on CDDP-induced apoptosis in chemoresistant p53-mutant ovarian cancer cells with/without Akt down-regulation. Apoptosis rate was evaluated with difference concentration of PRIMA-1 (0–10 μM) plus CDDP (0 or 10 μM) using adenoviral DN-Akt (_____) or LacZ (…….; as control). *** P<0.001; PRIMA-1+CDDP & DN-Akt vs. PRIMA-1 & DN-Akt; +++ P<0.001, ++ P<0.01 ; PRIMA-1+CDDP & DN-Akt vs. PRIMA-1+CDDP & CTL; ### P<0.001, ## P<0.01 ; PRIMA-1+CDDP & DN-Akt vs. PRIMA-1 & CTL. Results are expressed as mean ± SEM of three independent experimentsBack to article page