Figure 4

Combination Index ( CI ) values applying to the sequenced combinations of a ) CB , b ) OX and c ) CH1 with BORT administered to the ovarian A2780, A2780^cisR , A2780^ZD0473R and SKOV - 3 cancer cell lines. CI values were calculated following 72 h treatments with the drugs at their equipotent ratios. CI values of <1, =1 and >1 indicate respectively synergism, additivity and antagonism in combined drug action.