Table 1 The KEGG pathway of the DEGs
Category | KEGG pathway term | Count | Genes | P-value |
|---|---|---|---|---|
Up-regulated DEGs | hsa00982 drug metabolism | 8 | CYP3A5, GSTM3, MAOA, … | 0.004592 |
hsa05200 pathways in cancer | 21 | WNT5A, BMP2, FGF9, … | 0.006931 | |
hsa00980 metabolism of xenobiotics by cytochrome P450 | 7 | AKR1C2, CYP3A5, GSTM3, … | 0.015153 | |
hsa00350 tyrosine metabolism | 6 | MAOA, ALDH1A3, AOX1, … | 0.015606 | |
hsa04610 complement and coagulation cascades | 7 | THBD, C3, CFH, TFPI, … | 0.028328 | |
hsa00330 arginine and proline metabolism | 6 | GATM, MAOA, GLS, MAOB, … | 0.032382 | |
hsa04510 focal adhesion | 13 | CAV2, CAV1, COL3A1, MET, … | 0.038664 | |
Down-regulated DEGs | hsa04110 cell cycle | 7 | CCNE1, CDKN2A, CCNB2, … BUB1B, | 1.06E-05 |
hsa04115 p53 signaling pathway | 5 | CCNE1, CDKN2A, CCNB2, … | 1.78E-04 | |
hsa05200 pathways in cancer | 7 | CCNE1, FGF18, CDKN2A, … | 0.002121 | |
hsa04114 oocyte meiosis | 4 | CCNE1, CCNB2, AURKA, … | 0.011244 |