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Table 2 Reproductive outcomes of patients exposed to GnRHa trigger and intensive luteal steroid support versus patients exposed to conventional hCG trigger for final follicular maturation

From: Impact of GnRH agonist triggering and intensive luteal steroid support on live-birth rates and ovarian hyperstimulation syndrome: a retrospective cohort study

 

GnRHa trigger plus intensive luteal steroid support (N = 363)

Conventional hCG trigger (N = 257)

p

Total FSH (IU)

1,500 (1,300-1,800)

1,650 (1,200-2,200)

0.12

Peak Oestradiol (E2) (pg/ml)

11,850 (8,700-15,395)

8,598 (5,510-12,350)

0.0001

LH on day of trigger (IU)

1.95 (1.21-3.48)

2.14 (1.28-3.49)

0.46

Follicles >12 mm

20 (17–25)

18 (16–21)

0.0001

Oocytes

19 (15–24)

18 (15–22)

0.02

Embryos

11 (7–15)

10 (7–13)

0.14

Embryo transfers (ET) (n,% of total cycles)

322 (88.7%)

213 (83%)

0.038

Cancellations of ET due to early signs of OHSS (n,% of total cycles)

2 (0.55%)

22 (8.6%)

<0.0001

Embryos transferred

3

3

 

Positive pregnancy test (n,%per cycle)

134 (36.9%)

112 (43.5%)

0.095

Clinical Pregnancy (n,%per cycle)

109 (30%)

77 (30%)

0.99

Implantation rate (n,%)

137/966 (14.2%)

106/639 (16.6%)

0.978

Miscarriages (n,% per cycle)

5 (1.4%)

15 (5.8%)

0.002

Live birth rate (n,% per cycle)

108 (29.8%)

75 (29.2%)

0.69

Multiple pregnancy rate (n,% of live-birth)

28 (25.9%)

29 (38.7%)

0.067

OHSS cases (severe) (n,% per cycle)

1 (0.3%)

18 (7%)

<0.0001

  1. Variables that are not normally distributed are expressed as median (25th-75th percentile).
  2. Outcome data are presented per cycle started unless otherwise stated.