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Table 1 RNA sequencing shows significant differences in transcriptomes of the EEC16 and OSEC lines

From: Novel three-dimensional in vitro models of ovarian endometriosis

Gene symbol Gene name OSEC11 expression EEC16 expression Fold change q-value
Highly expressed in EEC16      
HAS1 Hyaluronan synthase 1 0.19 148.84 777.83 0.00E + 00
NCAM1 Neural cell adhesion molecule 1 0.02 11.33 524.29 3.44E-08
CHL1 Cell adhesion molecule with homology to L1CAM 0.06 29.64 491.01 0.00E + 00
KRT19 Keratin 19 0.74 253.34 341.72 0.00E + 00
PAQR5,Y_RNA Progestin and adipoQ receptor family member V 0.34 101.55 301.90 3.07E-03
ODZ2 Odz, odd Oz/ten-m homolog 2 (Drosophila) 0.05 13.68 288.70 1.19E-06
FBLN2 Fibulin2 0.44 108.01 246.49 4.84E-11
SLC24A3 Solute carrier family 24 (sodium/potassium/calcium exchanger), member 31 0.02 4.47 244.08 4.34E-06
CDH20 Cadherin 20, type 2 0.05 12.94 242.76 5.11E-07
MST1R Macrophage stimulating 1 receptor (c-met-related tyrosine kinase) 0.02 4.09 238.53 2.60E-03
SLITRK5 SLIT and NTRK-like family, member 5 0.02 3.76 236.12 4.86E-06
KRT19P1 Keratin 19 pseudogene 1 0.07 15.32 222.27 6.83E-06
CATSPER2 Cation channel, sperm associated 2 0.01 2.39 172.42 1.99E-04
SLC35F3 Solute carrier family 35, member F3 0.03 3.89 147.18 6.17E-03
CCDC85A Coiled-coil domain containing 85A 0.04 5.32 145.01 1.46E-03
ALDH1A2 Aldehyde dehydrogenase 1 family, member A2 0.16 21.60 137.26 0.00E + 00
NOVA1 Neuro-oncological ventral antigen 1 0.04 4.50 123.52 6.61E-09
NEBL Nebulette, Actin-binding Z-disk protein 0.22 26.32 122.11 3.89E-13
AC121334.1,KIF21A Kinesin family member 21A 7.08 804.71 113.71 6.09E-04
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.02 2.17 107.18 6.71E-08
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 4.99 524.34 105.00 1.84E-05
MMEL1 Membrane metallo-endopeptidase-like 1 0.04 4.06 99.76 1.19E-02
SULT1E1 Sulfotransferase family 1E, estrogen-preferring, member 1 0.19 18.17 94.01 2.70E-05
PTPRD Protein tyrosine phosphatase, receptor type, D 0.03 2.64 90.18 2.44E-03
FBN2 Fibrillin 2 0.43 36.94 86.48 0.00E + 00
DIRAS3 DIRAS family, GTP-binding RAS-like 3 3.47 281.89 81.34 0.00E + 00
DSC2 Desmocollin 2 0.06 4.98 80.65 1.02E-09
CD7 CD7 molecule, T-cell leukemia antigen 0.78 62.57 80.60 1.34E-11
RSPO4 R-spondin 4 0.03 2.29 78.55 1.92E-02
C3AR1 Complement component 3a receptor 1 0.07 5.56 77.19 5.05E-05
Highly expressed in OSEC11      
H19,MIR675 H19, imprinted maternally expressed transcript (non-protein coding); microRNA675 79.38 0 NA 8.04E-12
AR Androgen receptor 4.16 0 NA 2.46E-09
CALCR Calcitonin receptor 3.19 0 NA 3.37E-06
DCSTAMP Dendrocyte expressed seven transmembrane protein 3.55 0 NA 1.37E-04
REN Renin 113.02 0 NA 2.81E-04
MGP Matrix Gla protein 56.34 0 NA 3.77E-04
KISS1 KiSS-1 metastasis-suppressor 98.79 0 NA 9.30E-04
RP11-13 L2.4   7.26 0 NA 1.21E-03
LEF1 Lymphoid enhancer-binding factor 1 4.58 0 NA 1.46E-03
HOXC12 Homeobox C12 9.19 0 NA 1.91E-03
DACH2 Dachshund homolog 2 (Drosophila) 2.62 0 NA 2.05E-03
LPL Lipoprotein lipase 0.88 0 NA 2.08E-03
WNT16 Wingless-type MMTV integration site family, member 16 2 0 NA 2.60E-03
PPP1R14A Protein phosphatase 1, regulatory (inhibitor) subunit 14A 10.01 0 NA 6.06E-03
WFDC1 WAP four-disulfide core domain 1 2.49 0 NA 6.57E-03
SOD3 Superoxide dismutase 3, extracellular 11.15 0 NA 6.65E-03
GSTM5 Glutathione S-transferase mu 5 2.37 0 NA 8.57E-03
MKRN3 Makorin ring finger protein 3 2.24 0 NA 9.50E-03
LINC00460 Long intergenic non-protein coding RNA 460 3.24 0 NA 9.83E-03
C8orf4 Chromosome 8 open reading frame 4 6.8 0 NA 1.20E-02
PPAPDC3 Phosphatidic acid phosphatase type 2 domain containing 3 3.84 0 NA 1.27E-02
LYPD1 LY6/PLAUR domain containing 1 4.58 0 NA 1.50E-02
RCSD1, RP3-455 J7.4 RCSD domain containing 1 1.64 0 NA 1.51E-02
ITIH3 Inter-alpha-trypsin inhibitor heavy chain 3 2.11 0 NA 1.59E-02
MAOB Monoamine oxidase B 1.13 0 NA 1.69E-02
HOXC11 Homeobox C11 1.68 0 NA 1.78E-02
ITPRIPL1 Inositol 1,4,5-trisphosphate receptor interacting protein-like 1 1.21 0 NA 1.96E-02
CD36 CD36 molecule (thrombospondin receptor) 1.88 0 NA 2.26E-02
KIAA1456 KIAA1456 1.59 0 NA 2.28E-02
IQGAP2 IQ motif containing GTPase activating protein 2 1.24 0 NA 2.46E-02
  1. As shown by whole transcriptome RNA sequencing, 1780 genes are differentially expressed between primary EEC16 and OSEC lines. The 60 most significantly differentially expressed genes are listed here.