Table 2 Intratumoral TAM densities and differentiation patterns in relation to clinical and pathological characteristics

Stage

(p = 0.023) ^#

(p = 0.206)

(p = 0.004) ^#

(p = 0.162)

(p = 0.828)

(p = 0.038) ^#

(p = 0.002) ^#

(p = 0.008) ^#

(p = 0.002) ^#

 I

30.2 ± 18.9

16.3 ± 12.1

14.0 ± 8.5

17.6 ± 12.1

10.2 ± 8.0

7.4 ± 5.2

12.7 ± 7.6

6.1 ± 4.5

6.6 ± 4.1

 II

36.2 ± 23.7

17.0 ± 11.1

19.2 ± 14.0

21.5 ± 14.0

11.3 ± 8.3

10.2 ± 7.6

14.7 ± 10.9

5.7 ± 3.4

9.0 ± 8.3

 III

49.5 ± 32.6

22.4 ± 14.7

27.0 ± 19.5

26.8 ± 19.0

12.3 ± 8.8

14.4 ± 13.3

22.7 ± 16.3

10.1 ± 9.1

12.6 ± 8.4

 IV

52.7 ± 47.7

22.4 ± 21.6

30.4 ± 24.5

23.5 ± 18.8

11.2 ± 12.3

12.4 ± 9.9

29.2 ± 28.4

11.2 ± 10.6

18.0 ± 18.7

Histotype

(p = 0.049) ^#

(p = 0.038) ^#

(p = 0.015) ^#

(p = 0.016) ^#

(p = 0.047) ^#

(p = 0.006) ^#

(p = 0.193)

(p = 0.150)

(p = 0.170)

 Serous

45.9 ± 33.9

22.3 ± 16.0

23.6 ± 18.1

25.1 ± 16.4

13.3 ± 9.8

11.9 ± 9.7

20.8 ± 18.5

9.1 ± 8.4

11.7 ± 11.3

 Mucinous

45.1 ± 28.2

15.1 ± 9.0

30.0 ± 20.1

27.3 ± 19.8

9.8 ± 6.1

17.5 ± 14.2

17.8 ± 9.8

5.3 ± 3.1

12.5 ± 7.5

 Endometrioid

26.9 ± 15.3

13.7 ± 8.4

13.2 ± 7.7

14.9 ± 10.1

8.1 ± 5.9

6.8 ± 5.1

12.1 ± 6.8

5.6 ± 3.4

6.4 ± 3.9

 Clear cell

26.2 ± 12.0

12.6 ± 4.4

13.6 ± 7.9

12.3 ± 5.0

6.8 ± 3.9

5.6 ± 2.7

13.8 ± 9.6

5.8 ± 4.2

8.0 ± 6.5

 Undifferentiated

34.8 ± 22.6

19.8 ± 13.3

15.0 ± 10.3

21.8 ± 16.0

13.2 ± 10.9

8.6 ± 5.9

13.0 ± 6.9

6.6 ± 2.9

6.4 ± 4.7

Grade

(p = 0.001) ^#

(p < 0.001) ^#

(p = 0.002) ^#

(p < 0.001) ^#

(p = 0.002) ^#

(p = 0.002) ^#

(p = 0.006) ^#

(p = 0.003) ^#

(p = 0.028) ^#

 G1

30.2 ± 18.2

13.0 ± 8.8

17.2 ± 12.3

17.6 ± 11.9

8.2 ± 6.2

9.4 ± 7.7

12.6 ± 7.7

4.8 ± 3.3

7.8 ± 5.9

 G2

34.1 ± 20.6

16.7 ± 9.8

17.4 ± 12.0

18.2 ± 11.5

9.9 ± 6.8

8.3 ± 6.0

15.9 ± 11.1

6.8 ± 4.1

9.1 ± 7.9

 G3

54.4 ± 37.5

25.5 ± 17.8

28.9 ± 21.6

30.4 ± 19.6

15.1 ± 10.8

15.3 ± 12.8

24.0 ± 20.8

10.4 ± 9.9

13.6 ± 12.3

Size of residual site

(p = 0.625)

(p = 0.650)

(p = 0.637)

(p = 0.963)

(p = 0.497)

(p = 0.595)

(p = 0.328)

(p = 0.077)

(p = 0.773)

 < 2 cm

39.6 ± 29.6

18.6 ± 13.8

20.9 ± 17.4

22.4 ± 16.0

11.6 ± 8.4

10.7 ± 10.1

17.2 ± 15.6

7.0 ± 6.5

10.2 ± 10.1

 ≥ 2 cm

42.8 ± 27.4

20.0 ± 14.1

22.7 ± 14.9

22.2 ± 15.7

10.3 ± 8.8

11.9 ± 8.6

20.6 ± 14.3

9.7 ± 8.0

10.8 ± 7.8

Characteristics

Islet/stroma ratio of*

Overall ratio of

Intra-islet ratio of

Intra-stroma ratio of

Total TAMs

M1 TAMs

M2 TAMs

M1/M2 TAMs*

M1/M2 TAMs*

M1/M2 TAMs*

Stage

(p = 0.054)

(p = 0.585)

(p = 0.406)

(p = 0.012) ^#

(p = 0.106)

(p = 0.490)

 I

1.3 ± 0.7

1.7 ± 1.2

1.1 ± 0.8

1.4± 0.5

1.8 ± 0.8

1.2 ± 0.7

 II

1.1 ± 0.6

1.5 ± 1.3

0.9 ± 0.7

1.5± 0.5

2.0 ± 0.9

1.4 ± 0.7

 III

0.9 ± 0.3

1.2 ± 0.9

0.8 ± 0.4

1.3± 0.6

1.6 ± 0.9

1.2 ± 0.7

 IV

0.9 ± 0.6

1.6 ± 2.6

1.0 ± 0.9

1.0± 0.5

1.3 ± 1.0

1.1 ± 0.7

Histotype

(p = 0.005) ^#

(p = 0.197)

(p = 0.073)

(p =0.129)

(p = 0.651)

(p = 0.377)

 Serous

1.1 ± 0.6

1.6 ± 1.2

1.0 ± 0.7

1.4± 0.5

1.8 ± 0.9

1.3 ± 0.7

 Mucinous

0.6 ± 0.2

0.6 ± 0.2

0.5 ± 0.3

1.5± 0.5

1.9 ± 0.6

1.5 ± 0.7

 Endometrioid

1.1 ± 0.6

1.6 ± 2.1

1.0 ± 0.3

1.3± 0.2

1.5 ± 0.9

1.2 ± 0.7

 Clear cell

1.0 ± 0.3

1.6 ± 1.3

1.0 ± 0.5

1.1± 0.5

1.6 ± 1.2

1.0 ± 0.6

 Undifferentiated

1.5 ± 0.8

1.6 ± 0.8

1.4 ± 1.0

1.6± 0.5

1.9 ± 0.9

1.5 ± 0.5

Grade

(p = 0.671)

(p = 0.228)

(p = 0.925)

(p =0.159)

(p = 0.504)

(p = 0.231)

 G1

1.0 ± 0.7

1.2 ± 0.8

0.9 ± 0.9

1.5± 0.6

1.8 ± 0.8

1.4 ± 0.7

 G2

1.1 ± 0.7

1.7 ± 1.7

1.0 ± 0.6

1.3 ± 0.5

1.6 ± 0.8

1.1 ± 0.6

 G3

1.0 ± 0.5

1.3 ± 1.1

0.9 ± 0.6

1.4± 0.6

1.8 ± 1.0

1.3 ± 0.7

Size of residual site

(p = 0.816)

(p = 0.533)

(p = 0.025) ^#

(p =0.059)

(p =0.004) ^#

(p = 0.689)

 < 2 cm

1.0 ± 0.5

1.5 ± 1.2

0.9 ± 0.6

1.4± 0.5

1.9 ± 0.9

1.2 ± 0.7

 ≥ 2 cm

1.1 ± 0.7

1.3 ± 1.7

1.2 ± 0.8

1.2± 0.6

1.3 ± 0.9

1.3 ± 0.7