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Table 2 Intratumoral TAM densities and differentiation patterns in relation to clinical and pathological characteristics

From: A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients

Characteristics Total TAM densities* M1 TAM densities* M2 TAM densities*
  Overall Islet Stroma Overall Islet Stroma Overall Islet Stroma
Stage (p = 0.023) # (p = 0.206) (p = 0.004) # (p = 0.162) (p = 0.828) (p = 0.038) # (p = 0.002) # (p = 0.008) # (p = 0.002) #
 I 30.2 ± 18.9 16.3 ± 12.1 14.0 ± 8.5 17.6 ± 12.1 10.2 ± 8.0 7.4 ± 5.2 12.7 ± 7.6 6.1 ± 4.5 6.6 ± 4.1
 II 36.2 ± 23.7 17.0 ± 11.1 19.2 ± 14.0 21.5 ± 14.0 11.3 ± 8.3 10.2 ± 7.6 14.7 ± 10.9 5.7 ± 3.4 9.0 ± 8.3
 III 49.5 ± 32.6 22.4 ± 14.7 27.0 ± 19.5 26.8 ± 19.0 12.3 ± 8.8 14.4 ± 13.3 22.7 ± 16.3 10.1 ± 9.1 12.6 ± 8.4
 IV 52.7 ± 47.7 22.4 ± 21.6 30.4 ± 24.5 23.5 ± 18.8 11.2 ± 12.3 12.4 ± 9.9 29.2 ± 28.4 11.2 ± 10.6 18.0 ± 18.7
Histotype (p = 0.049) # (p = 0.038) # (p = 0.015) # (p = 0.016) # (p = 0.047) # (p = 0.006) # (p = 0.193) (p = 0.150) (p = 0.170)
 Serous 45.9 ± 33.9 22.3 ± 16.0 23.6 ± 18.1 25.1 ± 16.4 13.3 ± 9.8 11.9 ± 9.7 20.8 ± 18.5 9.1 ± 8.4 11.7 ± 11.3
 Mucinous 45.1 ± 28.2 15.1 ± 9.0 30.0 ± 20.1 27.3 ± 19.8 9.8 ± 6.1 17.5 ± 14.2 17.8 ± 9.8 5.3 ± 3.1 12.5 ± 7.5
 Endometrioid 26.9 ± 15.3 13.7 ± 8.4 13.2 ± 7.7 14.9 ± 10.1 8.1 ± 5.9 6.8 ± 5.1 12.1 ± 6.8 5.6 ± 3.4 6.4 ± 3.9
 Clear cell 26.2 ± 12.0 12.6 ± 4.4 13.6 ± 7.9 12.3 ± 5.0 6.8 ± 3.9 5.6 ± 2.7 13.8 ± 9.6 5.8 ± 4.2 8.0 ± 6.5
 Undifferentiated 34.8 ± 22.6 19.8 ± 13.3 15.0 ± 10.3 21.8 ± 16.0 13.2 ± 10.9 8.6 ± 5.9 13.0 ± 6.9 6.6 ± 2.9 6.4 ± 4.7
Grade (p = 0.001) # (p < 0.001) # (p = 0.002) # (p < 0.001) # (p = 0.002) # (p = 0.002) # (p = 0.006) # (p = 0.003) # (p = 0.028) #
 G1 30.2 ± 18.2 13.0 ± 8.8 17.2 ± 12.3 17.6 ± 11.9 8.2 ± 6.2 9.4 ± 7.7 12.6 ± 7.7 4.8 ± 3.3 7.8 ± 5.9
 G2 34.1 ± 20.6 16.7 ± 9.8 17.4 ± 12.0 18.2 ± 11.5 9.9 ± 6.8 8.3 ± 6.0 15.9 ± 11.1 6.8 ± 4.1 9.1 ± 7.9
 G3 54.4 ± 37.5 25.5 ± 17.8 28.9 ± 21.6 30.4 ± 19.6 15.1 ± 10.8 15.3 ± 12.8 24.0 ± 20.8 10.4 ± 9.9 13.6 ± 12.3
Size of residual site (p = 0.625) (p = 0.650) (p = 0.637) (p = 0.963) (p = 0.497) (p = 0.595) (p = 0.328) (p = 0.077) (p = 0.773)
 < 2 cm 39.6 ± 29.6 18.6 ± 13.8 20.9 ± 17.4 22.4 ± 16.0 11.6 ± 8.4 10.7 ± 10.1 17.2 ± 15.6 7.0 ± 6.5 10.2 ± 10.1
 ≥ 2 cm 42.8 ± 27.4 20.0 ± 14.1 22.7 ± 14.9 22.2 ± 15.7 10.3 ± 8.8 11.9 ± 8.6 20.6 ± 14.3 9.7 ± 8.0 10.8 ± 7.8
Characteristics Islet/stroma ratio of* Overall ratio of Intra-islet ratio of Intra-stroma ratio of
  Total TAMs M1 TAMs M2 TAMs M1/M2 TAMs* M1/M2 TAMs* M1/M2 TAMs*
Stage (p = 0.054) (p = 0.585) (p = 0.406) (p = 0.012) # (p = 0.106) (p = 0.490)
 I 1.3 ± 0.7 1.7 ± 1.2 1.1 ± 0.8 1.4± 0.5 1.8 ± 0.8 1.2 ± 0.7
 II 1.1 ± 0.6 1.5 ± 1.3 0.9 ± 0.7 1.5± 0.5 2.0 ± 0.9 1.4 ± 0.7
 III 0.9 ± 0.3 1.2 ± 0.9 0.8 ± 0.4 1.3± 0.6 1.6 ± 0.9 1.2 ± 0.7
 IV 0.9 ± 0.6 1.6 ± 2.6 1.0 ± 0.9 1.0± 0.5 1.3 ± 1.0 1.1 ± 0.7
Histotype (p = 0.005) # (p = 0.197) (p = 0.073) (p =0.129) (p = 0.651) (p = 0.377)
 Serous 1.1 ± 0.6 1.6 ± 1.2 1.0 ± 0.7 1.4± 0.5 1.8 ± 0.9 1.3 ± 0.7
 Mucinous 0.6 ± 0.2 0.6 ± 0.2 0.5 ± 0.3 1.5± 0.5 1.9 ± 0.6 1.5 ± 0.7
 Endometrioid 1.1 ± 0.6 1.6 ± 2.1 1.0 ± 0.3 1.3± 0.2 1.5 ± 0.9 1.2 ± 0.7
 Clear cell 1.0 ± 0.3 1.6 ± 1.3 1.0 ± 0.5 1.1± 0.5 1.6 ± 1.2 1.0 ± 0.6
 Undifferentiated 1.5 ± 0.8 1.6 ± 0.8 1.4 ± 1.0 1.6± 0.5 1.9 ± 0.9 1.5 ± 0.5
Grade (p = 0.671) (p = 0.228) (p = 0.925) (p =0.159) (p = 0.504) (p = 0.231)
 G1 1.0 ± 0.7 1.2 ± 0.8 0.9 ± 0.9 1.5± 0.6 1.8 ± 0.8 1.4 ± 0.7
 G2 1.1 ± 0.7 1.7 ± 1.7 1.0 ± 0.6 1.3 ± 0.5 1.6 ± 0.8 1.1 ± 0.6
 G3 1.0 ± 0.5 1.3 ± 1.1 0.9 ± 0.6 1.4± 0.6 1.8 ± 1.0 1.3 ± 0.7
Size of residual site (p = 0.816) (p = 0.533) (p = 0.025) # (p =0.059) (p =0.004) # (p = 0.689)
 < 2 cm 1.0 ± 0.5 1.5 ± 1.2 0.9 ± 0.6 1.4± 0.5 1.9 ± 0.9 1.2 ± 0.7
 ≥ 2 cm 1.1 ± 0.7 1.3 ± 1.7 1.2 ± 0.8 1.2± 0.6 1.3 ± 0.9 1.3 ± 0.7
  1. *The data are represented as mean ± standard deviation.
  2. #Statistical significance, ANOVA.