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Table 4 Multivariate Cox regression analysis of clinical, pathological, and TAM-related prognostic factors for ovarian cancer*

From: A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients

Parameters HR 95% CI p value
Age    0.234
 < 40 1 (reference) -  
 40 - 49 1.016 (0.205, 4.931)  
 50 - 59 1.664 (0.386, 7.181)  
 60 - 69 1.239 (0.292, 5.253)  
 ≥ 70 0.329 (0.043, 2.492)  
Gravidity    0.726
 0 - 1 1 (reference) -  
 2 - 3 1.000 (0.424, 2.355)  
 4 - 5 0.904 (0.345, 2.367)  
 ≥ 5 0.612 (0.184, 2.031)  
Parity    0.851
 0 - 1 1 (reference) -  
 2 - 3 1.068 (0.536, 2.129)  
Menopause    0.944
 Yes 1 (reference) -  
 No 0.969 (0.407, 2.304)  
Ascites    0.120
 Yes 1 (reference) -  
 No 0.421 (0.142, 1.252)  
Peritoneal metastasis    <0.001#
 Yes 1 (reference) -  
 No 10.753 (3.768, 30.685)  
Lymphatic metastasis    0.678
 Yes 1 (reference) -  
 No 0.814 (0.307, 2.156)  
Stage    <0.001#
 I 1 (reference) -  
 II 3.5 (0.781, 15.677)  
 III 6.1 (1.733, 21.469)  
 IV 38.5 (7.377, 200.926)  
Histotype    0.003#
 Serous 1 (reference) -  
 Mucinous 0.119 (0.017, 0.855)  
 Endometrioid 0.560 (0.116, 2.707)  
 Clear cell 0.780 (0.146, 4.159)  
 Undifferentiated 5.952 (1.339, 26.451)  
Grade    0.002#
 G1 1 (reference) -  
 G2 4.557 (2.373, 8.753)  
 G3 8.197 (2.456, 27.362)  
Size of residual site    0.008#
 < 2 cm 1 (reference) -  
 ≥ 2 cm 2.786 (1.307, 5.937)  
Overall M1/M2 TAM ratio    0.013#
 < 1.371 1 (reference) -  
 ≥ 1.371 0.448 (0.238, 0.842)  
  1. *A representative table for multivariate Cox regression analysis is shown for TAM-related parameters (i.e., overall M1/M2 TAM ratio). For the HRs of other TAM-related parameters, see Additional file 1: Tables S1-S14.
  2. #Statistical significance.